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When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulinCdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatinTwo E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin bindingThe human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phaseCDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiationProliferating cell nuclear antigen-dependent rapid recruitment of Cdt1 and CRL4Cdt2 at DNA-damaged sites after UV irradiation in HeLa cells.Cdt1 is differentially targeted for degradation by anticancer chemotherapeutic drugs.Premature chromosome condensation is induced by a point mutation in the hamster RCC1 geneCheckpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation.Nuclear RanGAP is required for the heterochromatin assembly and is reciprocally regulated by histone H3 and Clr4 histone methyltransferase in Schizosaccharomyces pombeCloning of Xenopus RCC1 cDNA, a homolog of the human RCC1 gene: complementation of tsBN2 mutation and identification of the product.A dual-specificity phosphatase Cdc25B is an unstable protein and triggers p34(cdc2)/cyclin B activation in hamster BHK21 cells arrested with hydroxyurea.Mitotic UV irradiation induces a DNA replication-licensing defect that potentiates G1 arrest response.The DNA replication fork blocked at the Ter site may be an entrance for the RecBCD enzyme into duplex DNA.Mismatch repair proteins recruited to ultraviolet light-damaged sites lead to degradation of licensing factor Cdt1 in the G1 phase.Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity.Schizosaccharomyces pombe RanGAP homolog, SpRna1, is required for centromeric silencing and chromosome segregation.Thymine DNA glycosylase modulates DNA damage response and gene expression by base excision repair-dependent and independent mechanisms.PCNA-dependent ubiquitination of Cdt1 and p21 in mammalian cells.Control of Genome Integrity by RFC Complexes; Conductors of PCNA Loading onto and Unloading from Chromatin during DNA Replication.Inhibition of DNA damage-induced apoptosis through Cdc7-mediated stabilization of Tob.Multiple ORC-binding sites are required for efficient MCM loading and origin firing in fission yeast.Geminin cleavage during apoptosis by caspase-3 alters its binding ability to the SWI/SNF subunit Brahma.Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines.Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair.A hamster temperature-sensitive G1 mutant, tsBN250 has a single point mutation in histidyl-tRNA synthetase that inhibits an accumulation of cyclin D1.tsBN75 and tsBN423, temperature-sensitive x-linked mutants of the BHK21 cell line, can be complemented by the ubiquitin-activating enzyme E1 cDNA.Cell cycle-dependent subcellular translocation of the human DNA licensing inhibitor geminin.Two different replication factor C proteins, Ctf18 and RFC1, separately control PCNA-CRL4Cdt2-mediated Cdt1 proteolysis during S phase and following UV irradiation.RanBP9 modulates AICD localization and transcriptional activity via direct interaction with Tip60.Mutations at multiple CDK phosphorylation consensus sites on Cdt2 increase the affinity of CRL4Cdt2 for PCNA and its ubiquitination activity in S phase.START-GAP2/DLC2 is localized in focal adhesions via its N-terminal region.Architecture of the complete oxygen-sensing FixL-FixJ two-component signal transduction system.Chromatin fractionation analysis of licensing factors in mammalian cells.Direct binding of Cdt2 to PCNA is important for targeting the CRL4 E3 ligase activity to Cdt1p65cdc18 plays a major role controlling the initiation of DNA replication in fission yeastSelf-organization of microtubule asters induced in Xenopus egg extracts by GTP-bound RanTemperature-sensitive defects of the GSP1gene, yeast Ran homologue, activate the Tel1-dependent pathwayIdentification of novel suppressors for Mog1 implies its involvement in RNA metabolism, lipid metabolism and signal transduction
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description
researcher ORCID ID = 0000-0001-5907-9380
@en
wetenschapper
@nl
name
Hideo Nishitani
@ast
Hideo Nishitani
@en
Hideo Nishitani
@es
Hideo Nishitani
@nl
type
label
Hideo Nishitani
@ast
Hideo Nishitani
@en
Hideo Nishitani
@es
Hideo Nishitani
@nl
prefLabel
Hideo Nishitani
@ast
Hideo Nishitani
@en
Hideo Nishitani
@es
Hideo Nishitani
@nl
P106
P1153
7102244333
P31
P496
0000-0001-5907-9380