Cooperative binding of acetaminophen and caffeine within the P450 3A4 active site.
about
A novel type of allosteric regulation: functional cooperativity in monomeric proteinsStructures of Cytochrome P450 2B4 Complexed with the Antiplatelet Drugs Ticlopidine and Clopidogrel,Understanding a substrate's product regioselectivity in a family of enzymes: a case study of acetaminophen binding in cytochrome P450sAlterations of chemotherapeutic pharmacokinetic profiles by drug-drug interactionsStructural features of cytochromes P450 and ligands that affect drug metabolism as revealed by X-ray crystallography and NMR.Preferred binding orientations of phenacetin in CYP1A1 and CYP1A2 are associated with isoform-selective metabolism.Interactions of cytochrome P450s with their ligands.NMR-derived models of amidopyrine and its metabolites in complexes with rabbit cytochrome P450 2B4 reveal a structural mechanism of sequential N-dealkylationDrug modulation of water-heme interactions in low-spin P450 complexes of CYP2C9d and CYP125A1.Current Approaches for Investigating and Predicting Cytochrome P450 3A4-Ligand InteractionsSubstrate binding to cytochromes P450.The structural basis for homotropic and heterotropic cooperativity of midazolam metabolism by human cytochrome P450 3A4.Cooperative properties of cytochromes P450.Plasticity of CYP2B enzymes: structural and solution biophysical methods.Spectroscopic features of cytochrome P450 reaction intermediatesMathematical model of LsrR-binding and derepression in Escherichia coli K12.Spectroscopic studies of the cytochrome P450 reaction mechanisms.Substrate proton to heme distances in CYP2C9 allelic variants and alterations by the heterotropic activator, dapsone.Association of prenatal exposure to acetaminophen and coffee with childhood asthma.Structure and function of cytochromes P450 2B: from mechanism-based inactivators to X-ray crystal structures and backπ-π Stacking mediated drug-drug interactions in human CYP2E1.Use of acetaminophen during pregnancy and risk of adverse pregnancy outcomes.Drug-Drug Interactions between Atorvastatin and Dronedarone Mediated by Monomeric CYP3A4.Membrane-embedded substrate recognition by cytochrome P450 3A4.
P2860
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P2860
Cooperative binding of acetaminophen and caffeine within the P450 3A4 active site.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Cooperative binding of acetaminophen and caffeine within the P450 3A4 active site.
@en
Cooperative binding of acetaminophen and caffeine within the P450 3A4 active site.
@nl
type
label
Cooperative binding of acetaminophen and caffeine within the P450 3A4 active site.
@en
Cooperative binding of acetaminophen and caffeine within the P450 3A4 active site.
@nl
prefLabel
Cooperative binding of acetaminophen and caffeine within the P450 3A4 active site.
@en
Cooperative binding of acetaminophen and caffeine within the P450 3A4 active site.
@nl
P2093
P356
P1476
Cooperative binding of acetaminophen and caffeine within the P450 3A4 active site.
@en
P2093
A Patricia Campbell
Arthur G Roberts
Michael D Cameron
Sidney D Nelson
William M Atkins
P304
P356
10.1021/TX7000702
P577
2007-09-26T00:00:00Z