about
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevityNutrient-sensitive mitochondrial NAD+ levels dictate cell survivalInhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and BeyondMSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae.HST2 mediates SIR2-independent life-span extension by calorie restriction.Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespanDepletion of Rictor, an essential protein component of mTORC2, decreases male lifespanTOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxOSex- and tissue-specific changes in mTOR signaling with age in C57BL/6J miceIntermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J MiceThe Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and AgingDecreased Consumption of Branched-Chain Amino Acids Improves Metabolic HealthThe role of protein arginine methylation in the formation of silent chromatinRapalogs and mTOR inhibitors as anti-aging therapeuticsEvidence for a common mechanism of SIRT1 regulation by allosteric activatorsHepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)Pharmacologic Means of Extending Lifespan.Rapamycin-induced metabolic defects are reversible in both lean and obese miceDiminished mTOR signaling: a common mode of action for endocrine longevity factors.Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system.Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages.Hot topics at the intersection of aging and energetics: Diabetes/insulin resistance, Sirtuins, and the Microbiome.The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism.mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft modelAkt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation.Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue.High-fat diet enhances stemness and tumorigenicity of intestinal progenitorsRapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island.Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profileYoung and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer.Regulation of metabolic health and aging by nutrient-sensitive signaling pathways.Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATP Channel Activity.Human MDR 1 protein overexpression delays the apoptotic cascade in Chinese hamster ovary fibroblasts.The TSC-mTOR pathway regulates macrophage polarization.Interleukin 6 protects pancreatic β cells from apoptosis by stimulation of autophagy.A radical role for TOR in longevity.mTORC2 takes the longevity stAGE.SYK kinase mediates brown fat differentiation and activation.
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P50
description
researcher
@en
wetenschapper
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հետազոտող
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name
Dudley W Lamming
@ast
Dudley W Lamming
@en
Dudley W Lamming
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Dudley W Lamming
@nl
Dudley W Lamming
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type
label
Dudley W Lamming
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Dudley W Lamming
@en
Dudley W Lamming
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Dudley W Lamming
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Dudley W Lamming
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prefLabel
Dudley W Lamming
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Dudley W Lamming
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Dudley W Lamming
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Dudley W Lamming
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Dudley W Lamming
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P106
P31
P496
0000-0002-0079-4467