about
High throughput mutagenesis for identification of residues regulating human prostacyclin (hIP) receptor expression and functionμ-opioid receptors: correlation of agonist efficacy for signalling with ability to activate internalization.Endomorphin-2: a biased agonist at the μ-opioid receptor.Long Receptor Residence Time of C26 Contributes to Super Agonist Activity at the Human β2 Adrenoceptor.Analysis of multiple histamine H₄ receptor compound classes uncovers Gαi protein- and β-arrestin2-biased ligands.Agonist-biased signaling at the histamine H4 receptor: JNJ7777120 recruits β-arrestin without activating G proteins.Efficacy is a contributing factor to the clinical onset of bronchodilation of inhaled beta(2)-adrenoceptor agonists.Regulation of cyclic AMP response-element binding-protein (CREB) by Gq/11-protein-coupled receptors in human SH-SY5Y neuroblastoma cells.Functional desensitization of the β 2 adrenoceptor is not dependent on agonist efficacy.An investigation into the structure-activity relationships associated with the systematic modification of the β(2)-adrenoceptor agonist indacaterol.ATP priming of macrophage-derived chemokine responses in CHO cells expressing the CCR4 receptor.Endogenous lysophosphatidic acid (LPA1 ) receptor agonists demonstrate ligand bias between calcium and ERK signalling pathways in human lung fibroblasts.The inhibition of human lung fibroblast proliferation and differentiation by Gs-coupled receptors is not predicted by the magnitude of cAMP response.Identification of novel IP receptor agonists using historical ligand biased chemical arrays
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P50
description
researcher ORCID ID = 0000-0001-6877-2320
@en
name
Elizabeth M Rosethorne
@ast
Elizabeth M Rosethorne
@en
Elizabeth M Rosethorne
@nl
type
label
Elizabeth M Rosethorne
@ast
Elizabeth M Rosethorne
@en
Elizabeth M Rosethorne
@nl
prefLabel
Elizabeth M Rosethorne
@ast
Elizabeth M Rosethorne
@en
Elizabeth M Rosethorne
@nl
P21
P31
P496
0000-0001-6877-2320