about
Gene trap mutagenesis of hnRNP A2/B1: a cryptic 3' splice site in the neomycin resistance gene allows continued expression of the disrupted cellular geneImpaired DNA replication within progenitor cell pools promotes leukemogenesis.Evolved Cellular Mechanisms to Respond to Genotoxic Insults: Implications for Radiation-Induced Hematologic MalignanciesEssential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene lociChallenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age?Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutationsStochastic modeling reveals an evolutionary mechanism underlying elevated rates of childhood leukemiaThe landscape of somatic mutations in protein coding genes in apparently benign human tissues carries signatures of relaxed purifying selectionPatterns of somatically acquired amplifications and deletions in apparently normal tissues of ovarian cancer patientsAging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitorsCancer evolution is associated with pervasive positive selection on globally expressed genesEvolved tumor suppression: why are we so good at not getting cancer?How cancer shapes evolution, and how evolution shapes cancerIrradiation selects for p53-deficient hematopoietic progenitors.Publishing flow cytometry dataE2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis.Inhibiting tyrosine phosphorylation of protein kinase Cδ (PKCδ) protects the salivary gland from radiation damageWnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl.Inhibition of calcineurin combined with dasatinib has direct and indirect anti-leukemia effects against BCR-ABL1(+) leukemia.Solution characterization of the extracellular region of CD147 and its interaction with its enzyme ligand cyclophilin ASurprising dependency for retinoblastoma protein in ras-mediated tumorigenesisUsing functional genomics to overcome therapeutic resistance in hematological malignancies.Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis.Recombinant adenoviral vectors can induce expression of p73 via the E4-orf6/7 proteinMutation-specific control of BCR-ABL T315I positive leukemia with a recombinant yeast-based therapeutic vaccine in a murine modelSimultaneous activation of Kras and inactivation of p53 induces soft tissue sarcoma and bladder urothelial hyperplasia.Lack of significant association between serum inflammatory cytokine profiles and the presence of colorectal adenomaTyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations.Aging-associated changes in hematopoiesis and leukemogenesis: what's the connection?E2F3 activity is regulated during the cell cycle and is required for the induction of S phase.E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis.PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer.Declining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations.The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state.Adenoviral-mediated gene transfer in lymphocytes.Relative fitness of hematopoietic progenitors influences leukemia progression.Targeting developmental pathways in children with cancer: what price success?Deficiency of mitochondrial modulator MCJ promotes chemoresistance in breast cancer.Trisomy 21 consistently activates the interferon response.Irradiation alters selection for oncogenic mutations in hematopoietic progenitors.
P50
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P50
description
researcher
@en
name
J DeGregori
@en
J DeGregori
@nl
type
label
J DeGregori
@en
J DeGregori
@nl
prefLabel
J DeGregori
@en
J DeGregori
@nl
P106
P31
P496
0000-0002-1287-1976