Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl. - Wikidata - thesis-toulmin - TriplyDB

Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl.

Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl.

http://www.wikidata.org/entity/Q33996893

about

ABL tyrosine kinases: evolution of function, regulation, and specificity Chemotherapeutic agents circumvent emergence of dasatinib-resistant BCR-ABL kinase mutations in a precise mouse model of Philadelphia chromosome-positive acute lymphoblastic leukemia Aberrant Wnt Signaling in Leukemia Narrowing the focus: a toolkit to systematically connect oncogenic signaling pathways with cancer phenotypes Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation The p53 circuit board Knockout Serum Replacement Promotes Cell Survival by Preventing BIM from Inducing Mitochondrial Cytochrome C Release ABL fusion oncogene transformation and inhibitor sensitivity are mediated by the cellular regulator RIN1.Tumor suppressor DYRK1A effects on proliferation and chemoresistance of AML cells by downregulating c-Myc.Growth of tyrosine kinase inhibitor-resistant Philadelphia-positive acute lymphoblastic leukemia: Role of bone marrow stromal cells Inhibition of calcineurin combined with dasatinib has direct and indirect anti-leukemia effects against BCR-ABL1(+) leukemia.Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1).Wnt/β-catenin pathway regulates ABCB1 transcription in chronic myeloid leukemia.Using functional genomics to overcome therapeutic resistance in hematological malignancies.Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A.Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations.Galectin-3 (Gal-3) induced by leukemia microenvironment promotes drug resistance and bone marrow lodgment in chronic myelogenous leukemia Molecular perturbations restrict potential for liver repopulation of hepatocytes isolated from non-heart-beating donor rats.Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche.Role in tumor growth of a glycogen debranching enzyme lost in glycogen storage disease.Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival.NFAT as cancer target: mission possible?Study of Arsenic Sulfide in Solid Tumor Cells Reveals Regulation of Nuclear Factors of Activated T-cells by PML and p53.Antitumor activity of a potent MEK inhibitor, TAK-733, against colorectal cancer cell lines and patient derived xenografts.WNT5A-NFAT signaling mediates resistance to apoptosis in pancreatic cancer First-line treatment of chronic myeloid leukaemia.Targeting developmental pathways in children with cancer: what price success?Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition.NFAT5 represses canonical Wnt signaling via inhibition of β-catenin acetylation and participates in regulating intestinal cell differentiation.PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells.CXXC5 (retinoid-inducible nuclear factor, RINF) is a potential therapeutic target in high-risk human acute myeloid leukemia Kch1 family proteins mediate essential responses to endoplasmic reticulum stresses in the yeasts Saccharomyces cerevisiae and Candida albicans.ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.Phospho-sulindac inhibits pancreatic cancer growth: NFATc1 as a drug resistance candidate CML cells actively evade host immune surveillance through cytokine-mediated downregulation of MHC-II expression.Chronic myeloid leukemia stem cells and developing therapies.Development of an effective therapy for chronic myelogenous leukemia NFAT gene family in inflammation and cancer.While at Rome miRNA and TRAIL do whatever BCR-ABL commands to do.Wnt signaling in normal and malignant hematopoiesis.

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Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl.

http://www.wikidata.org/entity/Q33996893

description

2010 nî lūn-bûn

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2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2010 թվականի հուլիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Wnt/Ca2+/NFAT signaling mainta ...... ls upon inhibition of Bcr-Abl.

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Wnt/Ca2+/NFAT signaling mainta ...... ls upon inhibition of Bcr-Abl.

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type

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Wnt/Ca2+/NFAT signaling mainta ...... ls upon inhibition of Bcr-Abl.

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Wnt/Ca2+/NFAT signaling mainta ...... ls upon inhibition of Bcr-Abl.

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Wnt/Ca2+/NFAT signaling mainta ...... ls upon inhibition of Bcr-Abl.

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Wnt/Ca2+/NFAT signaling mainta ...... ls upon inhibition of Bcr-Abl.

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J.CCR.2010.04.025

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Wnt/Ca2+/NFAT signaling mainta ...... lls upon inhibition of Bcr-Abl

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Christopher A Eide

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Danilo Perrotti

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Francesca Alvarez-Calderon

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Mark A Gregory

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Paolo Neviani

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Richard T Williams

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Thomas O'Hare

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Tzu L Phang

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Vadym Zaberezhnyy

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P2860

Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation

Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation

Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10

The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation

NF-AT-Driven interleukin-4 transcription potentiated by NIP45

Sequential involvement of NFAT and Egr transcription factors in FasL regulation

Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP

Ca(2+)/calmodulin-dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus

A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling

Transcriptional regulation by calcium, calcineurin, and NFAT

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45100276

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