sameAs
A 'specificity' pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinilAldose reductase regulates vascular smooth muscle cell proliferation by modulating G1/S phase transition of cell cycle.In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors.Inhibition of aldose reductase prevents growth factor-induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in human colon cancer cellsEffect of treating streptozotocin-induced diabetic rats with sorbinil, myo-inositol or aminoguanidine on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerveAldose reductase regulates high glucose-induced ectodomain shedding of tumor necrosis factor (TNF)-alpha via protein kinase C-delta and TNF-alpha converting enzyme in vascular smooth muscle cells.Inhibition of aldose reductase attenuates endotoxin signals in human non-pigmented ciliary epithelial cells.Role of aldose reductase in the high glucose induced expression of fibronectin in human mesangial cells.Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes.Effect of sorbinil and ascorbic acid on myo-inositol transport in cultured rat Schwann cells exposed to elevated extracellular glucose.The Effects of Streptozotocin-induced Diabetes and Aldose Reductase Inhibition with Sorbinil, on Left and Right Atrial Function in the RatThe effect of sorbinil, an aldose reductase inhibitor, on aortic function in control and streptozotocin-induced diabetic ratsThe effects of acetyl-L-carnitine and sorbinil on peripheral nerve structure, chemistry, and function in experimental diabetesTime-dependent aspects of osmolyte changes in rat kidney, urine, blood and lens with sorbinil and galactose feedingSorbinil prevention of diabetic-like retinopathy in the galactose-fed rat modelEffects of combined insulin and sorbinil treatment on diabetes-induced vascular dysfunction in ratsThe aldose reductase inhibitor sorbinil does not prevent the impairment in nitric oxide-mediated neurotransmission in anococcygeus muscle from diabetic ratsComparison of the effects of Zopolrestat and Sorbinil on lens myo-inositol influxThe sorbinil trap: a predicted dead-end complex confirms the mechanism of aldose reductase inhibition
P921
Q27739575-E5E09D65-C822-48DF-8352-85E2436AF7B5Q33848283-98F17846-42C3-47A9-A96C-7D60BEC2CEB3Q34153274-A378B746-1EF0-4C4D-AE94-D1434C1B0E2FQ34159639-4826F8BA-109D-4AB5-B335-FEA7AF05EB14Q36782199-686B9584-0FB5-46CD-9DB6-3F14607F385FQ37072778-D2D1EE5F-8727-405B-BFEC-02BEAA7C20E0Q40010526-9D9412A0-639D-48E4-9909-991E2EE5292EQ43263523-6D7B2F7C-9706-4D6E-918F-5E2688D559C7Q50042689-CB256C00-AEE9-4C73-B7F5-69520FBD1848Q54448552-AB9575B3-311D-4ABB-BEA2-F7471EF8118BQ59685497-D8586C3F-60E0-4B36-953C-A482003A90FEQ59685550-91DC2745-9EC1-4D1F-BBB1-F31FC7C9961CQ71220031-48C64739-2D87-4922-9165-05C48DE6129AQ71754623-04A9D949-6E48-4862-9414-C715A4CF313AQ71820941-D2A8327B-D7BB-46C7-A42D-54F41B76A1E9Q72366276-7FDD59B4-C66F-4DA6-B310-094D80158A6EQ73010663-B9E0A95E-3B0B-4585-8891-35F8A6429AA4Q73192398-EEA9C072-3A9A-404D-BA69-579249178223Q74138460-389FD5AD-0EF7-4EFC-9A1A-A610B47C63AA
P921
description
chemesch Verbindung
@lb
chemical compound
@en
chemical compound
@en-ca
chemical compound
@en-gb
chemická sloučenina
@cs
chemická zlúčenina
@sk
chemiese verbinding
@af
chemische Verbindung
@de
chemische Verbindung
@de-ch
chemische verbinding
@nl
name
Sorbinil
@sh
Sorbinil
@sr
Sorbinil
@sr-el
sorbinil
@en
Сорбинил
@sr-ec
سربینیل
@azb
سربینیل
@fa
type
label
Sorbinil
@sh
Sorbinil
@sr
Sorbinil
@sr-el
sorbinil
@en
Сорбинил
@sr-ec
سربینیل
@azb
سربینیل
@fa
altLabel
(S)-6-Fluorospiro(chroman-4,4'-imidazolidine)-2',5'-dione
@en
(S)-6-Fluorospiro(hroman-4,4'-imidazolidin)-2',5'-dion
@sr
C11H9FN2O3
@sr
CP 45634
@sr
CP-45634
@en
CP-45634
@sr
CP45634
@sr
sorbinol
@en
prefLabel
Sorbinil
@sh
Sorbinil
@sr
Sorbinil
@sr-el
sorbinil
@en
Сорбинил
@sr-ec
سربینیل
@azb
سربینیل
@fa
P638
P592
P6366
P646
P661
P662
P683
P117
P1579
P2017
C1COC2=C([C@]13C(=O)NC(=O)N3)C=C(C=C2)F
P2067
P2275
sorbinil
@en
P231
68367-52-2
P232
P233
C1COC2=C(C13C(=O)NC(=O)N3)C=C(C=C2)F