P527
P688
Specific localization of the guanosine triphosphate (GTP) cyclohydrolase I-immunoreactivity in the human brain3' deletions cause aniridia by preventing PAX6 gene expressionGTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytesAugmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cellsRole of human GTP cyclohydrolase I and its regulatory protein in tetrahydrobiopterin metabolismLocalization of GTP cyclohydrolase I in human peripheral blood smears using a specific monoclonal antibody and an immune-alkaline phosphatase labeling techniqueThe assays of activities and function of TH, AADC, and GCH1 and their potential use in ex vivo gene therapy of PDThe application of 8-aminoguanosine triphosphate, a new inhibitor of GTP cyclohydrolase I, to the purification of the enzyme from human liverGTP cyclohydrolase I utilizes metal-free GTP as its substrateGTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisationHereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I geneNovel mutations in the guanosine triphosphate cyclohydrolase 1 gene associated with DYT5 dystoniaCharacterization of mouse and human GTP cyclohydrolase I genes. Mutations in patients with GTP cyclohydrolase I deficiencyCritical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathwaysCytokine-stimulated GTP cyclohydrolase I expression in endothelial cells requires coordinated activation of nuclear factor-kappaB and Stat1/Stat3Cytokines stimulate GTP cyclohydrolase I gene expression in cultured human umbilical vein endothelial cellsA yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactionsPteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMPDiscovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular riskPurification of GTP cyclohydrolase I from human liver and production of specific monoclonal antibodiesThe neurobiology of tetrahydrobiopterin biosynthesis: a model for regulation of GTP cyclohydrolase I gene transcription within nigrostriatal dopamine neuronsZinc plays a key role in human and bacterial GTP cyclohydrolase IProteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions
P921
Q22254652-628FB195-1900-422A-9A98-C0841D05AF81Q24290547-3B0BEC95-DE7D-434E-AE1E-48AE4386EB1EQ24293818-F9E3B087-FE91-448E-9DD4-25D21F647248Q24295227-BA958E4C-D0D5-4246-B9B4-77C611D79E3EQ24296249-F272D9BF-E26E-413B-958A-4C0665323D80Q24298003-D30C9E59-9072-4458-9546-A36AEC9B03C2Q24298406-F7B848EC-6111-4540-AAE6-904FF21A1F45Q24299654-446A5E81-754D-4066-94A4-60876EF2C6E0Q24304340-A78D812D-00ED-46C5-B0DC-C7D89505B75BQ24304352-6734A4C8-C9E1-4ABB-AAF5-01E0B16B0696Q24314922-A3E54224-A99F-4C51-A313-74F7CCFCD88EQ24314935-AEC8E773-7633-4FD2-B8D2-01AB30124D4DQ24315857-655B40AA-E47C-47A4-A258-A44B93F55A98Q24322688-4212CF85-1AEE-4061-B823-B9A21DBF7482Q24323220-4B98FD2D-95A5-4968-B69C-9ABD8070B100Q24323362-FC6B1DD5-B75A-4380-9945-0F8E8F74E1A0Q24337076-59AFAB28-920B-48FE-9CCC-FCF4B1F3E4AEQ24337529-6E8FF151-BD25-4172-B3A8-BE3601F77550Q24338261-A1BE1C7C-355D-4777-B596-07EF3F3CDB73Q24339388-7767068B-CD69-42DD-B20B-54CFCA9EADD4Q27004679-08C5B9A3-17BE-45AE-A850-2675E0BB25DEQ27628605-04E5F7F9-BFFC-4678-B42C-27EC6110D878Q28116132-9226AF82-9CF5-4618-AC8F-31293DA1C310
P921
description
Protein
@de
mammalian protein found in Homo sapiens
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in GTP cyclohydrolase 1
@nl
protèin
@ace
protéine
@fr
بروتين في الإنسان العاقل
@ar
name
GCH1
@cy
GCH1
@uk
GTP ciklohidrolaza I
@sh
GTP ciklohidrolaza I
@sr
GTP cyclohydrolase 1
@en
GTP cyclohydrolase 1
@nl
GTP-Cyclohydrolase I
@de
GTP环水解酶I
@zh
ציקלוהידראז רדוקטאז
@he
type
label
GCH1
@cy
GCH1
@uk
GTP ciklohidrolaza I
@sh
GTP ciklohidrolaza I
@sr
GTP cyclohydrolase 1
@en
GTP cyclohydrolase 1
@nl
GTP-Cyclohydrolase I
@de
GTP环水解酶I
@zh
ציקלוהידראז רדוקטאז
@he
altLabel
GCH1
@en
GTP cyclohydrolase I
@de
GTP cyclohydrolase I
@en
GTP-CH-I
@en
dystonia 14
@en
guanosine 5'-triphosphate cyclohydrolase I
@en
prefLabel
GCH1
@cy
GCH1
@uk
GTP ciklohidrolaza I
@sh
GTP ciklohidrolaza I
@sr
GTP cyclohydrolase 1
@en
GTP cyclohydrolase 1
@nl
GTP-Cyclohydrolase I
@de
GTP环水解酶I
@zh
ציקלוהידראז רדוקטאז
@he
P637
P680
P681
P682
P705
P352
P6366
P638
P646
P31
P352
P6366
2775956414
P637
NP_001019195
NP_001019241
NP_001019242
XP_016876707
P646
P680
P681
P682
P702
P703
P705
ENSP00000378890
ENSP00000419045
ENSP00000444011
ENSP00000445246
ENSP00000477796