about
P688
Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeletonSerine phosphorylation by SYK is critical for nuclear localization and transcription factor function of IkarosPerinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase SykSyk expression and novel function in a wide variety of tissuesCritical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cellsStructural basis for the requirement of two phosphotyrosine residues in signaling mediated by Syk tyrosine kinaseAssociation of p72syk with the src homology-2 (SH2) domains of PLC gamma 1 in B lymphocytesDifferential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinasesInhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase FgrCEACAM1 negatively regulates IL-1β production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complexScaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRISyk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosisReconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinaseThe Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagenIntegrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifsNontranscriptional regulation of SYK by the coactivator OCA-B is required at multiple stages of B cell developmentThe Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signalingSyk tyrosine kinase required for mouse viability and B-cell developmentRhoH plays critical roles in Fc epsilon RI-dependent signal transduction in mast cellsRegulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.Selective regulation of Lyn tyrosine kinase by CD45 in immature B cellsSyk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectinsMultimolecular signaling complexes enable Syk-mediated signaling of CD36 internalizationThe tyrosine kinase Syk differentially regulates Toll-like receptor signaling downstream of the adaptor molecules TRAF6 and TRAF3Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteinsProtein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epitheliumSyk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorptionDisruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinaseNeutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infectionCD14 controls the LPS-induced endocytosis of Toll-like receptor 4Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12)TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of SykSTAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress.SYK kinase mediates brown fat differentiation and activation.Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophilsThe orphan nuclear receptor NR4A1 promotes FcεRI-stimulated mast cell activation and anaphylaxis by counteracting the inhibitory LKB1/AMPK axis
P921
Q24293554-5F08DF1F-9F06-449E-AC7C-0BCB50B745A3Q24301012-856EA856-9C6D-4F1C-B2CC-DA3672260C74Q24303475-E8754155-01BB-423E-BE9F-771C60384F0BQ28202066-0831A817-DCA1-4473-95C0-68F30148C8D6Q28505184-323538CC-FBB5-4B50-8693-A972DABDFB84Q28506637-96E1AE2D-F944-4F40-B807-D6D2E1CA30F9Q28507324-64CBE3E8-254C-494C-B18D-A5B59B010B87Q28507413-75B0F3B9-3071-43AE-9604-08EF521AC83FQ28507457-85C3F40F-23B9-4EC3-A183-EA9147401DCEQ28509313-83DEB273-9A6A-404E-93FA-BFC17B838147Q28510791-7FEF5565-7921-4C3E-BE76-465A67391AA3Q28511752-6BFE9FCA-E54B-479C-970A-85F53CE7BECFQ28512458-AD555297-E188-4C2A-9256-B60E3D9C7BEDQ28570295-0F3A7666-ED67-4C68-8A56-8F1913A4F330Q28584694-FDDDF1F8-29CF-4D1B-9A6F-9E4A406B8A53Q28585779-D8A0C6A9-E9D3-4752-B6B9-4577BDA64485Q28585980-96FEA0F7-FB8E-4A26-B417-B4A1A3D9D958Q28586244-DC782EAA-C22B-43A1-B9D9-26EDD8BB472FQ28586985-357F0B59-8C4F-4060-BCAD-EF3137FD2031Q28587800-8CEE5DFD-E60E-4022-8C53-70EDD72318FAQ28588103-43F67560-CFC1-49C2-9D98-34810440D6EFQ28588373-49F3DA1C-F1AC-4539-9A11-34A7C84ED771Q28588506-B5A57F10-653C-4FCC-BD45-12E25C0EDC9DQ28589223-229632EA-DB2C-49C5-BC9D-25ACFA727721Q28590988-881FE13E-478E-427B-A3D2-5D871DC8C42BQ28591689-E434B644-7952-4DF0-8169-F1AC01120520Q28592515-C1A14674-E3A1-42C6-91A8-2A09E41CCF92Q28592760-E0EBF014-030C-445B-A4E2-F958F6C1E52FQ28593717-CB71C687-8C58-4347-AAA9-EDECB8BF28F0Q28594089-1F058C03-1A2E-40B2-BE5A-5809CA90236AQ28594101-588A8C21-4D86-44FC-A476-B7029B5F0BF9Q28594672-1D180C6B-29C9-4752-9615-3C37A30B66F8Q28854385-CFFF20DE-25E2-4EF3-86E1-454B00ABAE9CQ33733773-7B880288-B453-4F27-8A4C-7CCD48F1AB1AQ47132970-42291875-2385-4485-9EA3-312F092D3E09Q54833632-85538834-AC00-4050-947A-275B6D7AB411Q64375475-037F45A3-675F-4594-8586-04AE1577FAB7
P921
description
mammalian protein found in Mus musculus
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Spleen tyrosine kinase
@nl
protèin
@ace
protéine
@fr
بروتين في فأر المنازل
@ar
name
Spleen tyrosine kinase
@en
Spleen tyrosine kinase
@nl
type
label
Spleen tyrosine kinase
@en
Spleen tyrosine kinase
@nl
altLabel
Syk
@en
tyrosine-protein kinase SYK
@en
prefLabel
Spleen tyrosine kinase
@en
Spleen tyrosine kinase
@nl
P361
P527
P637
P680
P681
P682
P705
P352
P31
P352
P361
P527
P637
NP_001185906
XP_006516958
XP_006516960
XP_017170959
XP_017170960
P680
P681
P682
P702
P703
P705
ENSMUSP00000060828
ENSMUSP00000112914
ENSMUSP00000113852