Syk tyrosine kinase required for mouse viability and B-cell development
about
The Syk tyrosine kinase suppresses malignant growth of human breast cancer cellsSerine phosphorylation by SYK is critical for nuclear localization and transcription factor function of IkarosA congenital mutation of the novel gene LRRC8 causes agammaglobulinemia in humansGerminal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activationThe kinase Syk as an adaptor controlling sustained calcium signalling and B-cell developmentIdentification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activationLatent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinasesPositive and negative regulation of T-cell activation through kinases and phosphatasesDistinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor functionDifferential effects of B cell receptor and B cell receptor-FcgammaRIIB1 engagement on docking of Csk to GTPase-activating protein (GAP)-associated p62Activation of the Syk tyrosine kinase is insufficient for downstream signal transduction in B lymphocytes.Targeting Syk in Autoimmune Rheumatic DiseasesDevelopment of the mammalian lymphatic vasculatureInflammation and vascular injury: basic discovery to drug developmentManagement of chronic lymphocytic leukemia (CLL) in the era of B-cell receptor signal transduction inhibitorsAKT induces transcriptional activity of PU.1 through phosphorylation-mediated modifications within its transactivation domainBLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteinsPhosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor functionTyrosine phosphorylation and translocation of LAT in plateletsSLP76 and SLP65: complex regulation of signalling in lymphocytes and beyondThe non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation.Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinasesRegulation of B-1 cell activation and its autoantibody production by Lyn kinase-regulated signallingsSyk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130A Novel Triazolopyridine-Based Spleen Tyrosine Kinase Inhibitor That Arrests Joint InflammationPhosphorylation of Syk activation loop tyrosines is essential for Syk function. An in vivo study using a specific anti-Syk activation loop phosphotyrosine antibodyThe Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagenThe Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signalingRegulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.Phospholipase Cgamma2 provides survival signals via Bcl2 and A1 in different subpopulations of B cellsDisruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinaseNeutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infectionFAM46 proteins are novel eukaryotic non-canonical poly(A) polymerasesShc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytesThe Syk family of protein tyrosine kinases in T-cell activation and developmentEnhancement of B-cell receptor signaling by a point mutation of adaptor protein 3BP2 identified in human inherited disease cherubism.Tyrosine phosphorylation of 3BP2 regulates B cell receptor-mediated activation of NFATTyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease.Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3Syk-dependent actin dynamics regulate endocytic trafficking and processing of antigens internalized through the B-cell receptor
P2860
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P248
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P2860
Syk tyrosine kinase required for mouse viability and B-cell development
description
1995 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Nature
@fr
artículu científicu espublizáu en 1995
@ast
scientific journal article
@en
vedecký článok (publikovaný 1995/11/16)
@sk
vědecký článek publikovaný v roce 1995
@cs
wetenschappelijk artikel (gepubliceerd op 1995/11/16)
@nl
наукова стаття, опублікована в листопаді 1995
@uk
مقالة علمية (نشرت في 16-11-1995)
@ar
name
Syk tyrosine kinase required for mouse viability and B-cell development
@ast
Syk tyrosine kinase required for mouse viability and B-cell development
@en
Syk tyrosine kinase required for mouse viability and B-cell development
@nl
type
label
Syk tyrosine kinase required for mouse viability and B-cell development
@ast
Syk tyrosine kinase required for mouse viability and B-cell development
@en
Syk tyrosine kinase required for mouse viability and B-cell development
@nl
prefLabel
Syk tyrosine kinase required for mouse viability and B-cell development
@ast
Syk tyrosine kinase required for mouse viability and B-cell development
@en
Syk tyrosine kinase required for mouse viability and B-cell development
@nl
P2093
P921
P3181
P356
P1433
P1476
Syk tyrosine kinase required for mouse viability and B-cell development
@en
P2093
P2888
P304
P3181
P356
10.1038/378303A0
P407
P577
1995-11-16T00:00:00Z
P6179
1014814455