about
P688
Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6Functional analysis of human MLH1 and MSH2 missense variants and hybrid human-yeast MLH1 proteins in Saccharomyces cerevisiaeATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adductsRibonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repairMutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female miceTargeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasiaLocalization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase IMutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stagesThe cohesin subunit RAD21L functions in meiotic synapsis and exhibits sexual dimorphism in fertilityMeiotic failure in male mice lacking an X-linked factorTumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repairMouse HFM1/Mer3 is required for crossover formation and complete synapsis of homologous chromosomes during meiosisRole for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctionsCharacterization of a novel meiosis-specific protein within the central element of the synaptonemal complexReduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymesSeparation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genesA defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient miceMlh1 mediates tissue-specific regulation of mitotic recombinationDifferent mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modificationsMlh1 can function in antibody class switch recombination independently of Msh2Genomic instability in mice lacking histone H2AXMouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsisElevated mutant frequencies and increased C : G-->T : A transitions in Mlh1-/- versus Pms2-/- murine small intestinal epithelial cellsMammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sitesThe Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosisRoles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesisDifferent mutator phenotypes in Mlh1- versus Pms2-deficient miceMeiotic arrest and aneuploidy in MLH3-deficient miceMeikin is a conserved regulator of meiosis-I-specific kinetochore functionContributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouseAlignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein
P921
Q22242924-CC62E9DA-F88A-44A9-968A-541B5A0BA347Q24291685-086D8C37-AEF5-40BE-8A41-765A6A2CBF27Q24337520-CE2D93DA-9395-48A8-BE7E-A3485B641025Q24338799-3B03852B-8B2C-45E7-9C2D-8159956ADCCFQ24606421-0BABE830-E893-4B12-8B80-C0DB67ADBD70Q28201015-0EBFEF03-95DF-4E29-A401-0804F8BAED8DQ28505426-D28C8DE7-6FE9-4DAF-9873-65CB37FEB299Q28506028-1A9EC5E4-5157-4A5B-A0D1-4EEAA584F5ABQ28507130-B3B86CB2-31BE-4F4C-8B78-618E5A04C53BQ28507751-5855FF69-773A-441C-AB9A-C06D4372BEE5Q28508905-03DC2555-B232-4A49-A649-A2F52A513B72Q28512386-6412CFEB-AB1D-47FA-9C73-3A973DC461D7Q28513507-4DA78721-6DC9-4EAE-95FF-D8A9A098E573Q28569784-94968DC2-5DB0-4A96-9420-C14B220EFF32Q28585862-30C7B597-2028-4922-A4DC-25362604999CQ28586442-A820ADE6-AE51-44CE-B19F-13EDF965B4A7Q28586540-6D35B8F9-1C27-4176-A42A-6FD6C7721DE6Q28586588-DFA3D590-6C27-45AB-8B69-542A748F729AQ28586687-10FB2BAB-9BE7-40A7-A459-FC5A6518A870Q28587810-C640211E-A79E-4756-A905-7CED7BAEA0D2Q28589826-BADFAE1E-5090-4E21-976C-4D1C6FE46243Q28591450-19B37F25-CEE3-4ADE-AC01-4C4BD4C2252EQ28592033-931D602D-9E0E-4AF0-8EF8-AA66F1B29FEFQ28592214-44677EB8-B30B-4BD7-829D-F9D3325D6A70Q28592328-2B6CE2E3-F5D7-440E-B1AD-459477AF8A89Q28592821-927B4553-C3E8-42AA-AD36-840AE441BF85Q28592891-D4E833BF-3FD1-4B65-8B58-F71B215C5B50Q28593875-09B90323-8CE5-42AC-8CCB-1D9DF69FCEC9Q28593959-C40CBF91-3D0F-4176-B5AC-145C41DDAAC0Q28594406-CDA40BDD-8D28-475F-8614-E55EE3FB25D0Q28771502-0EA78D17-2FE3-446F-B8AA-0AF0B74A0B6D
P921
description
mammalian protein found in Mus musculus
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in MutL homolog 1
@nl
protèin
@ace
protéine
@fr
بروتين في فأر المنازل
@ar
name
MutL homolog 1
@en
MutL homolog 1
@nl
type
label
MutL homolog 1
@en
MutL homolog 1
@nl
altLabel
DNA mismatch repair protein Mlh1
@en
Mlh1
@en
colon cancer, nonpolyposis type 2
@en
mutL protein homolog 1
@en
prefLabel
MutL homolog 1
@en
MutL homolog 1
@nl
P361
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P31
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P361
P527
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NP_001311451
XP_006512011
XP_006512014
XP_011241237
XP_030099939
P680
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P702
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ENSMUSP00000035079
ENSMUSP00000119170
ENSMUSP00000142563
ENSMUSP00000143786