Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes
about
Lack of MSH2 involvement differentiates V(D)J recombination from other non-homologous end joining eventsIgH chain class switch recombination: mechanism and regulationMSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sitesShifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctionsSomatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution patternRole for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctionsAltered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant miceMsh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombinationMlh1 can function in antibody class switch recombination independently of Msh2Genomic instability in mice lacking histone H2AXExamination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversificationGrowth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPFUpdate on the hyper immunoglobulin M syndromesHuman MutL homolog (MLH1) function in DNA mismatch repair: a prospective screen for missense mutations in the ATPase domain.Unique DNA repair gene variations and potential associations with the primary antibody deficiency syndromes IgAD and CVIDThe liaison of isotype class switch and mismatch repair: an illegitimate affair.ATM increases activation-induced cytidine deaminase activity at downstream S regions during class-switch recombination.Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and developmentSwitch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination.PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance.Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutationMolecular regulation of class switch recombination to IgE through epsilon germline transcription.Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination.Rad9 is required for B cell proliferation and immunoglobulin class switch recombinationLinking class-switch recombination with somatic hypermutation.DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse.Regulation of hypermutation by activation-induced cytidine deaminase phosphorylationMechanism and regulation of class switch recombinationAID and mismatch repair in antibody diversification.Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining.De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination.Complex relationship between mismatch repair proteins and MBD4 during immunoglobulin class switch recombinationAccessibility control and machinery of immunoglobulin class switch recombination.Class-switch recombination: after the dawn of AID.Hyper-IgM syndrome type 4 with a B lymphocyte-intrinsic selective deficiency in Ig class-switch recombination.What role for AID: mutator, or assembler of the immunoglobulin mutasome?Mismatch-mediated error prone repair at the immunoglobulin genes.p53 represses class switch recombination to IgG2a through its antioxidant functionThe catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination
P2860
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P2860
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes
description
1999 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1999
@ast
im August 1999 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 1999/08/02)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/08/02)
@nl
наукова стаття, опублікована в серпні 1999
@uk
مقالة علمية (نشرت في 2-8-1999)
@ar
name
Reduced isotype switching in s ...... ent in mismatch repair enzymes
@ast
Reduced isotype switching in s ...... ent in mismatch repair enzymes
@en
Reduced isotype switching in s ...... ent in mismatch repair enzymes
@nl
type
label
Reduced isotype switching in s ...... ent in mismatch repair enzymes
@ast
Reduced isotype switching in s ...... ent in mismatch repair enzymes
@en
Reduced isotype switching in s ...... ent in mismatch repair enzymes
@nl
prefLabel
Reduced isotype switching in s ...... ent in mismatch repair enzymes
@ast
Reduced isotype switching in s ...... ent in mismatch repair enzymes
@en
Reduced isotype switching in s ...... ent in mismatch repair enzymes
@nl
P2093
P2860
P921
P356
P1476
Reduced isotype switching in s ...... ent in mismatch repair enzymes
@en
P2093
J Stavnezer
R Kucherlapati
W Edelmann
P2860
P304
P356
10.1084/JEM.190.3.323
P407
P577
1999-08-01T00:00:00Z