sameAs
Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrateGuidelines for the use and interpretation of assays for monitoring autophagyThe corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradationSingle-nucleotide polymorphisms in the p53 pathway regulate fertility in humansAn African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse modelThe role of the p53 tumor suppressor in metabolism and diabetesBID regulation by p53 contributes to chemosensitivityStructural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocketp53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expressionWnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells.CSF1 is a novel p53 target gene whose protein product functions in a feed-forward manner to suppress apoptosis and enhance p53-mediated growth arrest.Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.Identification and characterization of small molecule human papillomavirus E6 inhibitorsMitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.Wild-type and mutant p53 proteins interact with mitochondrial caspase-3Regulation of female reproduction by p53 and its family membersTissue-specific apoptotic effects of the p53 codon 72 polymorphism in a mouse model.Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.Interaction of the ARF tumor suppressor with cytosolic HSP70 contributes to its autophagy functionSmall-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory AxisA conserved domain in exon 2 coding for the human and murine ARF tumor suppressor protein is required for autophagy induction.Polymorphisms in the p53 pathway.Polymorphic variants in the p53 pathway.Subtelomeric p53 binding prevents accumulation of DNA damage at human telomeres.The HSP70 family and cancerThe P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction.ARF induces autophagy by virtue of interaction with Bcl-xl.HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors.ARF, autophagy and tumor suppression.Heat shock proteins regulate activation-induced proteasomal degradation of the mature phosphorylated form of protein kinase C.The p53 family and programmed cell deathAcetylation of the DNA binding domain regulates transcription-independent apoptosis by p53.Ironing out how p53 regulates ferroptosis.Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition.P53 represses pyrimidine catabolic gene dihydropyrimidine dehydrogenase (DPYD) expression in response to thymidylate synthase (TS) targeting.PUMA-dependent apoptosis in NSCLC cancer cells by a dimeric β-carboline.Genetic Modifiers of the p53 Pathway.Inhibition of stress-inducible HSP70 impairs mitochondrial proteostasis and function.The codon 72 polymorphism of p53 influences cell fate following nutrient deprivation.Efficacy of the HSP70 inhibitor PET-16 in multiple myeloma.
P50
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P50
description
American cancer rearcher
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onderzoeker
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հետազոտող
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Maureen E. Murphy
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Maureen Murphy
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Maureen Murphy
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Maureen Murphy
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Maureen Murphy
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Maureen Murphy
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Maureen Murphy
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Maureen Murphy
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مورین مورفی
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Maureen E. Murphy
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Maureen Murphy
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Maureen Murphy
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Maureen Murphy
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Maureen Murphy
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Maureen Murphy
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Maureen Murphy
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Maureen Murphy
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مورین مورفی
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Maureen E Murphy
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Maureen E. Murphy
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Maureen E. Murphy
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Maureen E. Murphy
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Maureen E. Murphy
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Maureen Murphy
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Maureen Murphy
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Maureen Murphy
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Maureen Murphy
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Maureen Murphy
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Maureen Murphy
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Maureen Murphy
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P108
P1153
7403900157
P21
P31
P496
0000-0001-7644-7296