Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrate
about
Structural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocketA novel Hsp70 inhibitor prevents cell intoxication with the actin ADP-ribosylating Clostridium perfringens iota toxinRole of membrane Hsp70 in radiation sensitivity of tumor cellsMutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions.How hsp70 molecular machines interact with their substrates to mediate diverse physiological functions.Intracellular antigens as targets for antibody based immunotherapy of malignant diseases.Present Yourself! By MHC Class I and MHC Class II Molecules.Promiscuous binding by Hsp70 results in conformational heterogeneity and fuzzy chaperone-substrate ensembles.Novel Entropically Driven Conformation-specific Interactions with Tomm34 Protein Modulate Hsp70 Protein Folding and ATPase Activities.A disulfide-bonded DnaK dimer is maintained in an ATP-bound stateAllosteric fine-tuning of the conformational equilibrium poises the chaperone BiP for post-translational regulationNoncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling.Conformation transitions of the polypeptide-binding pocket support an active substrate release from Hsp70s.Sensitizing tumor cells to conventional drugs: HSP70 chaperone inhibitors, their selection and application in cancer models.Interplay between recombinant Hsp70 and proteasomes: proteasome activity modulation and ubiquitin-independent cleavage of Hsp70.Domain Mapping of Heat Shock Protein 70 Reveals That Glutamic Acid 446 and Arginine 447 Are Critical for Regulating Superoxide Dismutase 2 Function.Hsp70's RNA-binding and mRNA-stabilizing activities are independent of its protein chaperone functions.Steady-State Levels of Phosphorylated Mitogen-Activated Protein Kinase Kinase 1/2 Determined by Mortalin/HSPA9 and Protein Phosphatase 1 Alpha in KRAS and BRAF Tumor Cells.Fingerprints of Conformational States of Human Hsp70 at Sub-THz FrequenciesWhole exome sequencing reveals HSPA1L as a genetic risk factor for spontaneous preterm birth
P2860
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P2860
Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrate
description
2014 nî lūn-bûn
@nan
2014 թուականին հրատարակուած գիտական յօդուած
@hyw
2014 թվականին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
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name
Crystal structure of the stres ...... complex with peptide substrate
@ast
Crystal structure of the stres ...... complex with peptide substrate
@en
Crystal structure of the stres ...... complex with peptide substrate
@en-gb
Crystal structure of the stres ...... complex with peptide substrate
@nl
type
label
Crystal structure of the stres ...... complex with peptide substrate
@ast
Crystal structure of the stres ...... complex with peptide substrate
@en
Crystal structure of the stres ...... complex with peptide substrate
@en-gb
Crystal structure of the stres ...... complex with peptide substrate
@nl
altLabel
Crystal Structure of the Stres ...... Complex with Peptide Substrate
@en
prefLabel
Crystal structure of the stres ...... complex with peptide substrate
@ast
Crystal structure of the stres ...... complex with peptide substrate
@en
Crystal structure of the stres ...... complex with peptide substrate
@en-gb
Crystal structure of the stres ...... complex with peptide substrate
@nl
P2093
P2860
P1433
P1476
Crystal structure of the stres ...... complex with peptide substrate
@en
P2093
Donna L George
Julia I-Ju Leu
Pingfeng Zhang
P2860
P304
P356
10.1371/JOURNAL.PONE.0103518
P407
P577
2014-01-01T00:00:00Z