Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signallingSmall-molecule inhibition of APT1 affects Ras localization and signalingStructures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylationIdentification of pyrazolopyridazinones as PDEδ inhibitors.Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferaseStructure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPaseDevelopment of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complexAnalysis of the eukaryotic prenylome by isoprenoid affinity taggingDesign, synthesis, and characterization of peptide-based rab geranylgeranyl transferase inhibitorsIdentification and structure of small-molecule stabilizers of 14-3-3 protein-protein interactionsDesign and evaluation of fragment-like estrogen receptor tetrahydroisoquinoline ligands from a scaffold-detection approachStructure-guided development of selective RabGGTase inhibitorsArl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargoCrystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterasesAn optimised small-molecule stabiliser of the 14-3-3-PMA2 protein-protein interactionPsoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTaseQuantitative Analysis of Prenylated RhoA Interaction with Its Chaperone, RhoGDIDevelopment of selective, potent RabGGTase inhibitorsNatural-product-derived fragments for fragment-based ligand discoveryNeuritogenic militarinone-inspired 4-hydroxypyridones target the stress pathway kinase MAP4K4Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX AssociationEpiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1Allosteric regulation of substrate binding and product release in geranylgeranyltransferase type IIFarnesylation of Ras is important for the interaction with phosphoinositide 3-kinase gammaCrystallization and preliminary X-ray diffraction analysis of the Rab escort protein-1 in complex with Rab geranylgeranyltransferaseAn acylation cycle regulates localization and activity of palmitoylated Ras isoformsDistinct Signaling Requirements for the Establishment of ESC Pluripotency in Late-Stage EpiSCsA crowdsourcing evaluation of the NIH chemical probesProtein structure similarity as guiding principle for combinatorial library design.Compound library development guided by protein structure similarity clustering and natural product structureProtein structure similarity clustering and natural product structure as guiding principles in drug discovery.Protein structure similarity clustering (PSSC) and natural product structure as inspiration sources for drug development and chemical genomics.Charting biologically relevant chemical space: a structural classification of natural products (SCONP)Design of compound libraries based on natural product scaffolds and protein structure similarity clustering (PSSC).Protein structure similarity clustering: dynamic treatment of PDB structures facilitates clustering.Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation.A ligand-directed divergent catalytic approach to establish structural and functional scaffold diversity.Bioactivity-guided navigation of chemical space.Bioorthogonal chemistry for site-specific labeling and surface immobilization of proteins.Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor.
P50
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P50
description
Duits scheikundige
@nl
German chemist
@en
German chemist
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German chemist
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Saksamaa keemik
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ceimiceoir Gearmánach
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chimist german
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chimiste allemand
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deutscher Chemiker
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Herbert Waldmann
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Herbert Waldmann
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Herbert Waldmann
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Herbert Waldmann
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Herbert Waldmann
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Herbert Waldmann
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Herbert Waldmann
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Herbert Waldmann
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Herbert Waldmann
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Herbert Waldmann
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Herbert Waldmann
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Herbert Waldmann
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Herbert Waldmann
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Herbert Waldmann
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Herbert Waldmann
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Herbert Waldmann
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Herbert Waldmann
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prefLabel
Herbert Waldmann
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Herbert Waldmann
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Herbert Waldmann
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Herbert Waldmann
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Herbert Waldmann
@en
Herbert Waldmann
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Herbert Waldmann
@fr
Herbert Waldmann
@it
Herbert Waldmann
@nb
Herbert Waldmann
@nds
P108
P166
P463
P1006
P214
P227
P244
P268
P269
P1006
P1053
B-7406-2017