Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo
about
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signallingStructural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119.The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteinsRegulation of small GTPases by GEFs, GAPs, and GDIsMolecular views of Arf-like small GTPases in cilia and ciliopathiesIdentification of pyrazolopyridazinones as PDEδ inhibitors.Quantitative Analysis of Prenylated RhoA Interaction with Its Chaperone, RhoGDIPDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinityDaughter cell identity emerges from the interplay of Cdc42, septins, and exocytosisARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targetingHabenular commissure formation in zebrafish is regulated by the pineal gland-specific gene unc119cMembrane protein transport in photoreceptors: the function of PDEδ: the Proctor lectureA semisynthetic Atg3 reveals that acetylation promotes Atg3 membrane binding and Atg8 lipidation.Unc119 gene deletion partially rescues the GRK1 transport defect of Pde6d (- /-) cones.Identification and characterisation of the RalA-ERp57 interaction: evidence for GDI activity of ERp57.The ARL2 GTPase is required for mitochondrial morphology, motility, and maintenance of ATP levels.Small-molecule modulation of Ras signaling.Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1.Mistrafficking of prenylated proteins causes retinitis pigmentosa 2.The abundance of the ARL2 GTPase and its GAP, ELMOD2, at mitochondria are modulated by the fusogenic activity of mitofusins and stressors.Expression and subcellular distribution of UNC119a, a protein partner of transducin α subunit in rod photoreceptors.The prenyl-binding protein PrBP/δ: a chaperone participating in intracellular traffickingUncoordinated (UNC)119: coordinating the trafficking of myristoylated proteins.G-protein signaling leverages subunit-dependent membrane affinity to differentially control βγ translocation to intracellular membranes.Ras GTPase activating (RasGAP) activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes.Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathwayArf-like Protein 3 (ARL3) Regulates Protein Trafficking and Ciliogenesis in Mouse Photoreceptors.Mutations in ARL2BP, encoding ADP-ribosylation-factor-like 2 binding protein, cause autosomal-recessive retinitis pigmentosaProtein sorting, targeting and trafficking in photoreceptor cellsInteraction of aryl hydrocarbon receptor-interacting protein-like 1 with the farnesyl moietyVPS35 binds farnesylated N-Ras in the cytosol to regulate N-Ras traffickingRPGR, a prenylated retinal ciliopathy protein, is targeted to cilia in a prenylation- and PDE6D-dependent manner.ARL3 regulates trafficking of prenylated phototransduction proteins to the rod outer segment.Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ.Higher order signaling: ARL2 as regulator of both mitochondrial fusion and microtubule dynamics allows integration of 2 essential cell functions.A homozygous PDE6D mutation in Joubert syndrome impairs targeting of farnesylated INPP5E protein to the primary cilium.Regulating the regulator: post-translational modification of RASAmino acid sensing mechanisms: an Achilles heel in cancer?Crosstalk of small GTPases at the Golgi apparatus.
P2860
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P2860
Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo
description
2011 nî lūn-bûn
@nan
2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo
@ast
Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo
@en
Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo
@nl
type
label
Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo
@ast
Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo
@en
Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo
@nl
prefLabel
Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo
@ast
Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo
@en
Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo
@nl
P2093
P50
P3181
P356
P1476
Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo
@en
P2093
Alexandra Rusinova
Anchal Chandra
Martin Bierbaum
Philippe I H Bastiaens
Yong-Xiang Chen
P2888
P3181
P356
10.1038/NCHEMBIO.686
P577
2011-10-16T00:00:00Z
P6179
1009158263