Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediateAIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASCCytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesionsSilica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilizationA mammalian microRNA expression atlas based on small RNA library sequencingAdvances in CRISPR-Cas9 genome engineering: lessons learned from RNA interferenceOf inflammasomes and pathogens--sensing of microbes by the inflammasomeImmunology in clinic review series; focus on autoinflammatory diseases: inflammasomes: mechanisms of activationSpecies-specific detection of the antiviral small-molecule compound CMA by STINGStructures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 ReceptorStructural mechanism of cytosolic DNA sensing by cGASMolecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation5'-Triphosphate RNA is the ligand for RIG-IThe AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA virusesCutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expressionThe NALP3 inflammasome is involved in the innate immune response to amyloid-betaNLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystalsSuperior immunogenicity of inactivated whole virus H5N1 influenza vaccine is primarily controlled by Toll-like receptor signalling.Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4.iGLuc: a luciferase-based inflammasome and protease activity reporter.cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.A ligation-independent cloning technique for high-throughput assembly of transcription activator–like effector genesSAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.RIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cellsCutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome.Influenza virus adaptation PB2-627K modulates nucleocapsid inhibition by the pathogen sensor RIG-I.Control of hepatitis C virus replication in mouse liver-derived cells by MAVS-dependent production of type I and type III interferons.Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signalingAIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis.A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome ActivationcGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells.Functional IRF3 deficiency in a patient with herpes simplex encephalitis.Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retinaMITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment.Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNAPhosphorylation of murine SAMHD1 regulates its antiretroviral activityATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.
P50
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P50
description
Duits hoogleraar
@nl
German university teacher
@en
German university teacher
@en-ca
German university teacher
@en-gb
Saksamaa ülikooli õppejõud
@et
deutscher Mediziner (Immunologe)
@de
léachtóir ollscoile Gearmánach
@ga
profesor universitar german
@ro
profesor universitar gjerman
@sq
profesor universitario alemán
@es
name
Veit Hornung
@ast
Veit Hornung
@ca
Veit Hornung
@da
Veit Hornung
@de
Veit Hornung
@en
Veit Hornung
@es
Veit Hornung
@fr
Veit Hornung
@it
Veit Hornung
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Veit Hornung
@nl
type
label
Veit Hornung
@ast
Veit Hornung
@ca
Veit Hornung
@da
Veit Hornung
@de
Veit Hornung
@en
Veit Hornung
@es
Veit Hornung
@fr
Veit Hornung
@it
Veit Hornung
@nds
Veit Hornung
@nl
prefLabel
Veit Hornung
@ast
Veit Hornung
@ca
Veit Hornung
@da
Veit Hornung
@de
Veit Hornung
@en
Veit Hornung
@es
Veit Hornung
@fr
Veit Hornung
@it
Veit Hornung
@nds
Veit Hornung
@nl
P108
P166
P214
P227
P1053
C-3565-2012
P106
P1153
6603665800
P1412
P1559
Veit Hornung
@de
P19
P21
P213
0000 0000 1650 5346
P214
P227
P31
P3829
P496
0000-0002-4150-194X
P569
1976-04-15T00:00:00Z