Gap junction mediated intercellular metabolite transfer in the cochlea is compromised in connexin30 null mice
about
Early development of the vertebrate inner earThe role of connexins in ear and skin physiology - functional insights from disease-associated mutationsThe cochlea as an independent neuroendocrine organ: expression and possible roles of a local hypothalamic-pituitary-adrenal axis-equivalent signaling systemAberrant Cx26 hemichannels and keratitis-ichthyosis-deafness syndrome: insights into syndromic hearing lossMice with conditional deletion of Cx26 exhibit no vestibular phenotype despite secondary loss of Cx30 in the vestibular end organsConnexin30 null and conditional connexin26 null mice display distinct pattern and time course of cellular degeneration in the cochleaReduced Connexin26 in the Mature Cochlea Increases Susceptibility to Noise-Induced Hearing Lossin MiceVirally expressed connexin26 restores gap junction function in the cochlea of conditional Gjb2 knockout mice.Protection of spiral ganglion neurons from degeneration using small-molecule TrkB receptor agonists.7,8,3'-Trihydroxyflavone, a potent small molecule TrkB receptor agonist, protects spiral ganglion neurons from degeneration both in vitro and in vivoThe cochlear CRF signaling systems and their mechanisms of action in modulating cochlear sensitivity and protection against trauma.Calcium signaling in the cochlea - Molecular mechanisms and physiopathological implications.Different cellular and genetic basis of noise-related endocochlear potential reduction in CBA/J and BALB/cJ mice.BAAV mediated GJB2 gene transfer restores gap junction coupling in cochlear organotypic cultures from deaf Cx26Sox10Cre mice.The role of gap junction channels during physiologic and pathologic conditions of the human central nervous systemHearing loss associated with enlargement of the vestibular aqueduct: mechanistic insights from clinical phenotypes, genotypes, and mouse models.Molecular dynamics simulations of the Cx26 hemichannel: evaluation of structural models with Brownian dynamics.Early developmental expression of connexin26 in the cochlea contributes to its dominate functional role in the cochlear gap junctions.Virally mediated Kcnq1 gene replacement therapy in the immature scala media restores hearing in a mouse model of human Jervell and Lange-Nielsen deafness syndrome.Atoh1 directs the formation of sensory mosaics and induces cell proliferation in the postnatal mammalian cochlea in vivoTargeted connexin26 ablation arrests postnatal development of the organ of Corti.Diverse deafness mechanisms of connexin mutations revealed by studies using in vitro approaches and mouse models.Development of form and function in the mammalian cochlea.Connexins: sensors of epidermal integrity that are therapeutic targets.Connexins and gap junctions in the inner ear--it's not just about K⁺ recyclingMechanisms linking connexin mutations to human diseases.Human diseases associated with connexin mutations.Dominant connexin26 mutants associated with human hearing loss have trans-dominant effects on connexin30.Perinatal Gjb2 gene transfer rescues hearing in a mouse model of hereditary deafness.Dominant Cx26 mutants associated with hearing loss have dominant-negative effects on wild type Cx26.Early postnatal virus inoculation into the scala media achieved extensive expression of exogenous green fluorescent protein in the inner ear and preserved auditory brainstem response thresholds.DFNB1 Non-syndromic Hearing Impairment: Diversity of Mutations and Associated Phenotypes.The endocochlear potential as an indicator of reticular lamina integrity after noise exposure in mice.Prevention of cisplatin-induced ototoxicity by the inhibition of gap junctional intercellular communication in auditory cells.Impaired membrane targeting and aberrant cellular localization of human Cx26 mutants associated with inherited recessive hearing loss.Cochlear Gene Therapy for Sensorineural Hearing Loss: Current Status and Major Remaining Hurdles for Translational Success.Cx26 partial loss causes accelerated presbycusis by redox imbalance and dysregulation of Nfr2 pathway
P2860
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P2860
Gap junction mediated intercellular metabolite transfer in the cochlea is compromised in connexin30 null mice
description
2008 nî lūn-bûn
@nan
2008 թուականին հրատարակուած գիտական յօդուած
@hyw
2008 թվականին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Gap junction mediated intercel ...... omised in connexin30 null mice
@ast
Gap junction mediated intercel ...... omised in connexin30 null mice
@en
Gap junction mediated intercel ...... omised in connexin30 null mice
@en-gb
Gap junction mediated intercel ...... omised in connexin30 null mice
@nl
type
label
Gap junction mediated intercel ...... omised in connexin30 null mice
@ast
Gap junction mediated intercel ...... omised in connexin30 null mice
@en
Gap junction mediated intercel ...... omised in connexin30 null mice
@en-gb
Gap junction mediated intercel ...... omised in connexin30 null mice
@nl
altLabel
Gap Junction Mediated Intercel ...... omised in Connexin30 Null Mice
@en
prefLabel
Gap junction mediated intercel ...... omised in connexin30 null mice
@ast
Gap junction mediated intercel ...... omised in connexin30 null mice
@en
Gap junction mediated intercel ...... omised in connexin30 null mice
@en-gb
Gap junction mediated intercel ...... omised in connexin30 null mice
@nl
P2093
P2860
P1433
P1476
Gap junction mediated intercel ...... omised in connexin30 null mice
@en
P2093
Binfei Zhou
Qing Chang
Shoeb Ahmad
Wenxue Tang
P2860
P356
10.1371/JOURNAL.PONE.0004088
P407
P577
2008-01-01T00:00:00Z