about
P688
Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domainsMicroRNA-29b regulates the expression level of human progranulin, a secreted glycoprotein implicated in frontotemporal dementia.Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutationsSortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival.Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease.The lysosomal protein cathepsin L is a progranulin protease.Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair.MicroRNA-588 suppresses tumor cell migration and invasion by targeting GRN in lung squamous cell carcinoma.Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.
P921
Q24305310-DCE45318-4231-46A6-B7DE-421A6682B1D7Q30982718-98520DA9-FC14-4716-A397-B1C583F96DC6Q33815765-ABD134C8-75DB-4D19-90A4-04CF6B0DD849Q34346014-20453FCE-E010-43A9-925D-980E2011E32DQ36078240-DE2A4F62-2D91-4977-A979-4619FEDD2E15Q36527176-692AFED9-9155-4056-8A17-81BE261A7603Q37604580-CC1A8E18-791B-4C58-B517-8A9DFEE3A58BQ38661883-5431FC8C-97E9-4784-BAB9-D11B35BB4D4BQ38814424-FDE7BABC-D7BF-4EF2-BEEB-A622996D0CE8Q40677795-8B7EB691-0E4A-41A3-8E57-D4C64340FA39Q41232342-5029DF53-0B5D-46C1-9977-63775804BD21Q48363573-C399D3DF-422C-4B73-8D95-913B09D84205
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in Granulin precursor
@nl
protèin
@ace
بروتين في الإنسان العاقل
@ar
name
Granulin precursor
@en
type
label
Granulin precursor
@en
altLabel
GRN
@en
PC cell-derived growth factor
@en
PEPI
@en
acrogranin
@en
epithelin
@en
glycoprotein 88
@en
glycoprotein of 88 Kda
@en
granulin-epithelin
@en
granulins
@en
proepithelin
@en
prefLabel
Granulin precursor
@en
P637
P638
P680
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P682
P705
P352
P31
P352
P637
XP_005257310
XP_024306498
P638
P681
P682
P702
P703
P705
ENSP00000053867
ENSP00000465375
ENSP00000465518
ENSP00000465673
ENSP00000466271
ENSP00000466405
ENSP00000466611
ENSP00000466956
ENSP00000467022
ENSP00000467431