Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin. - Wikidata - wikimedia - TriplyDB

Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.

Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.

http://www.wikidata.org/entity/Q34346014

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The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains Mechanisms of Progranulin Action and Regulation in Genitourinary Cancers Molecular Pathways Bridging Frontotemporal Lobar Degeneration and Psychiatric Disorders Phenotypic Heterogeneity of Monogenic Frontotemporal Dementia Mechanisms of granulin deficiency: lessons from cellular and animal models Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis Potential mechanisms of progranulin-deficient FTLD Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk Potential roles of microglial cell progranulin in HIV-associated CNS pathologies and neurocognitive impairment Progranulin: at the interface of neurodegenerative and metabolic diseases Carcinogenic Parasite Secretes Growth Factor That Accelerates Wound Healing and Potentially Promotes Neoplasia A shift to organismal stress resistance in programmed cell death mutants Focal Adhesion Kinase-Dependent Role of the Soluble Form of Neurotensin Receptor-3/Sortilin in Colorectal Cancer Cell Dissociation A novel role for drebrin in regulating progranulin bioactivity in bladder cancer Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein Sortilin, encoded by the cardiovascular risk gene SORT1, and its suggested functions in cardiovascular disease Sortilin, a novel APOE receptor implicated in Alzheimer disease Progranulin, a glycoprotein deficient in frontotemporal dementia, is a novel substrate of several protein disulfide isomerase family proteins Inactivation of CDK/pRb pathway normalizes survival pattern of lymphoblasts expressing the FTLD-progranulin mutation c.709-1G>A Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency Mannose 6-phosphate receptor and sortilin mediated endocytosis of α-galactosidase A in kidney endothelial cells Increased Brain Neurotensin and NTSR2 Lead to Weak Nociception in NTSR3/Sortilin Knockout Mice Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway.A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells Clinicopathologic variability of the GRN A9D mutation, including amyotrophic lateral sclerosis The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases TMEM106B expression is reduced in Alzheimer's disease brains Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations Biomarkers in frontotemporal lobar degenerations--progress and challenges.Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.Progranulin protein levels are differently regulated in plasma and CSF.C-terminus of progranulin interacts with the beta-propeller region of sortilin to regulate progranulin trafficking.Frontotemporal dementia and its subtypes: a genome-wide association study.Altered microRNA expression in frontotemporal lobar degeneration with TDP-43 pathology caused by progranulin mutations.Progranulin transcripts with short and long 5' untranslated regions (UTRs) are differentially expressed via posttranscriptional and translational repression.Sortilin: an unusual suspect in cholesterol metabolism: from GWAS identification to in vivo biochemical analyses, sortilin has been identified as a novel mediator of human lipoprotein metabolism.

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Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.

http://www.wikidata.org/entity/Q34346014

description

2010 nî lūn-bûn

@nan

2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Sortilin-mediated endocytosis ...... dementia protein, progranulin.

@ast

Sortilin-mediated endocytosis ...... dementia protein, progranulin.

@en

Sortilin-mediated endocytosis ...... dementia protein, progranulin.

@nl

type

label

Sortilin-mediated endocytosis ...... dementia protein, progranulin.

@ast

Sortilin-mediated endocytosis ...... dementia protein, progranulin.

@en

Sortilin-mediated endocytosis ...... dementia protein, progranulin.

@nl

prefLabel

Sortilin-mediated endocytosis ...... dementia protein, progranulin.

@ast

Sortilin-mediated endocytosis ...... dementia protein, progranulin.

@en

Sortilin-mediated endocytosis ...... dementia protein, progranulin.

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J.NEURON.2010.09.034

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Sortilin-mediated endocytosis ...... dementia protein, progranulin

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Christian B Vægter

http://www.w3.org/2001/XMLSchema#string

Fenghua Hu

http://www.w3.org/2001/XMLSchema#string

Ian R Mackenzie

http://www.w3.org/2001/XMLSchema#string

Owen A Brady

http://www.w3.org/2001/XMLSchema#string

Thihan Padukkavidana

http://www.w3.org/2001/XMLSchema#string

Yanqiu Zheng

http://www.w3.org/2001/XMLSchema#string

P2860

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration

The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein

Sortilin is essential for proNGF-induced neuronal cell death

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.

A gene network regulating lysosomal biogenesis and function

The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin

Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain

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10.1016/J.NEURON.2010.09.034

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4

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68

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Stephen M. Strittmatter

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49624095

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21092856

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Granulin precursor

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2990962

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