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IL12A:IL12BIL10-downregulated extracellular proteins2xIL12B2xIL12B [extracellular region]IL12A:IL12B [endoplasmic reticulum lumen]IL12A:IL12B [Golgi lumen]IL12A:IL12B [late endosome lumen]IL12B:IL23AIL12B:IL23A [extracellular region]IL12B dimerizesIL12A binds IL12BInterleukin-12 binds Interleukin-12 receptorIL12B binds IL23AIL12B translocates from the cytosol to the extracellular region
P527
P688
Ovine interleukin 12 has biological activity on ovine and human activated peripheral blood mononuclear cellsNovel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cellsOvarian follicular concentration of IL-12, IL-15, IL-18 and p40 subunit of IL-12 and IL-23IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in ratsA receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23RICOS expression by activated human Th cells is enhanced by IL-12 and IL-23: increased ICOS expression enhances the effector function of both Th1 and Th2 cellsDifferential effects of insulin-like growth factor-1 and atheroma-associated cytokines on cell proliferation and apoptosis in plaque smooth muscle cells of symptomatic and asymptomatic patients with carotid stenosisDivergent effects of IL-12 and IL-23 on the production of IL-17 by human T cellsHuman IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activityIL-23 promotes growth and proliferation in human squamous cell carcinoma of the oral cavityIL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12UVB induces IL-12 transcription in human keratinocytes in vivo and in vitroRegulation of virus-induced IL-12 and IL-23 expression in human macrophagesDifferential effects of IL12 and IL2 on expression and function of cellular adhesion molecules on purified human natural killer cellsIL-23 and IL-12 responses in activated human T cells retrovirally transduced with IL-23 receptor variantsSevere mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patientsCloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cellsCommensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 developmentCoexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factorIL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 productionOverexpression of miR‑21 is involved in acute monocytic leukemia‑associated angiogenesis by targeting IL‑12
P921
Q50263117-29F98CD3-3366-4AD9-9CE5-21E1CB9CB662Q50263329-63721D67-4089-4F76-A42A-B2DDB13B18E8Q50263346-2130B062-5296-44D2-863D-4AF83D23B5C4Q50263348-08F77849-FCA9-4A14-B2C5-9752797A96E5Q50263350-9E2068F0-D9D4-416E-A829-43ABB787595AQ50263352-7CA20733-1880-4F6A-9791-EDC131A489FAQ50263353-B80C60AD-AC37-4902-94B5-AFFA0DF38956Q50263385-7C6404FC-EB75-4777-85DE-337E1D240359Q50263386-6273FB32-1153-42AC-98D4-5E30E2C67BC8Q50292779-D9852356-1C1F-4FA4-961D-C2FF3645A9D2Q50292781-7F58A90C-8126-4DCE-9712-A03623AB2707Q50292789-98D6ED4B-3262-4286-B8A5-F77C08841FE0Q50292841-5D95E72B-3564-4BAD-A7DB-8B4F8056CD93Q50292854-0AD7EFFC-7153-4E7C-9B6E-C173B77E3B94Q50292854-DD733AD5-B81A-4E6C-819E-84077697DF4F
P527
Q24290370-D9098A89-6631-439C-A14F-7DCFB305B485Q24290619-A05E8C10-CFCF-4C76-A1F3-23810BFF895EQ24293096-2A303916-896F-49B3-AEDB-E26F809F610FQ24293458-7D59EEE4-6C89-4408-BE07-D286E8CFAB4BQ24294661-09926AF8-BA35-4951-AD5B-4CD0CF159946Q24297906-2864C5F1-60FE-408E-A1F5-AE3A7EAB61C0Q24299856-96594348-0452-408D-B003-4371A3FB8527Q24301111-B2577B7F-E869-46BF-B75B-535FB68A3B2BQ24304986-BBF91147-80EE-4942-89E9-412786E553BAQ24306484-68B06D5A-0BFA-41D1-83FA-70891753BA79Q24308440-86328867-EFB8-464A-B2D3-5A2BF9338759Q24308711-1E3A9D38-662E-4E89-8702-C5EC1ABC92C5Q24312131-FC9EE32F-1D65-4FA5-8997-C36B42C50D09Q24317251-8AD6DE40-5EB9-4FF9-99B3-DAB92D1E1B08Q24318434-573B0208-EB48-40B1-AAE4-4C3355000EA9Q24319681-5CD82B63-4DC6-4FFA-8105-C94220E29B1AQ24320044-4E9C3025-7D6D-4B2A-BA18-C3553217A7A7Q24338229-97976196-26C9-45BE-9BE3-7EE8C1380F5CQ24338275-BAE7C714-26D6-4F00-B5E2-5ADEDA72F642Q24338518-73961057-7106-49B9-9E31-E28568A77457Q24338636-D19CEB6E-6A64-410C-9C89-5E8E0B030376Q90936279-754FABB6-FF69-402D-B0C9-16833135621D
P921
description
humanes Protein
@de
mammalian protein found in Homo sapiens
@en
menselijk eiwit
@nl
protein
@id
proteinë
@sq
protèin
@ace
protéine humaine
@fr
بروتين بشري
@ar
name
Interleukin 12B
@en
Interleukin 12B
@nl
type
label
Interleukin 12B
@en
Interleukin 12B
@nl
altLabel
CLMF p40
@en
IL-12 subunit p40
@en
IL12, subunit p40
@en
IL12B
@en
NK cell stimulatory factor chain 2
@en
NKSF2
@en
cytotoxic lymphocyte maturation factor 40 kDa subunit
@en
interleukin 12, p40
@en
interleukin 12B (natural kille ...... cyte maturation factor 2, p40)
@en
interleukin-12 beta chain
@en
prefLabel
Interleukin 12B
@en
Interleukin 12B
@nl
P361
P527
P638
P680
P681
P682
P352
P486
P637
P31
P352
P361
P486
P527
P637
P638
P680
P681
P682
P702
P703
P705
ENSP00000231228