Pharmacological brake-release of mRNA translation enhances cognitive memory
about
TBL2 is a novel PERK-binding protein that modulates stress-signaling and cell survival during endoplasmic reticulum stressExploring Internal Ribosome Entry Sites as Therapeutic TargetsThe unfolded protein response in neurodegenerative diseases: a neuropathological perspectiveCrystal structure of eukaryotic translation initiation factor 2BReview: Modulating the unfolded protein response to prevent neurodegeneration and enhance memoryDrosophila as an In Vivo Model for Human Neurodegenerative DiseaseTranslational control of auditory imprinting and structural plasticity by eIF2α.Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits.Endoplasmic reticulum stress-induced neuronal inflammatory response and apoptosis likely plays a key role in the development of diabetic encephalopathy.Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice.Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult.Role of Endoplasmic Reticulum Stress in Learning and Memory Impairment and Alzheimer's Disease-Like Neuropathology in the PS19 and APPSwe Mouse Models of Tauopathy and Amyloidosis.The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assemblyInsights into the mechanisms of eukaryotic translation gained with ribosome profilingTargeting axonal protein synthesis in neuroregeneration and degeneration.ER stress-induced eIF2-alpha phosphorylation underlies sensitivity of striatal neurons to pathogenic huntingtinTranslational control of mGluR-dependent long-term depression and object-place learning by eIF2α.Quantitative profiling of initiating ribosomes in vivo.Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation.G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases.Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.Unfolded Protein Response and PERK Kinase as a New Therapeutic Target in the Pathogenesis of Alzheimer's DiseaseImproved transcription and translation with L-leucine stimulation of mTORC1 in Roberts syndromeThe Power of Sophisticated Phenotypic Screening and Modern Mechanism-of-Action Methods.Translational Repression Protects Human Keratinocytes from UVB-Induced Apoptosis through a Discordant eIF2 Kinase Stress ResponseIre1-mediated decay in mammalian cells relies on mRNA sequence, structure, and translational statusPERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia.Integrated stress response is critical for gemcitabine resistance in pancreatic ductal adenocarcinomaModulation of p-eIF2α cellular levels and stress granule assembly/disassembly by trehalose.Smoking-Relevant Nicotine Concentration Attenuates the Unfolded Protein Response in Dopaminergic Neurons.An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response.Translational control in synaptic plasticity and cognitive dysfunctionTranslational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2αTranslational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine.The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress.Less translational control, more memory.Real-Time Imaging of Translation on Single mRNA Transcripts in Live CellsAttenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological ResponsesA liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution.eIF2α-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons.
P2860
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P2860
Pharmacological brake-release of mRNA translation enhances cognitive memory
description
2013 nî lūn-bûn
@nan
2013 թուականին հրատարակուած գիտական յօդուած
@hyw
2013 թվականին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Pharmacological brake-release of mRNA translation enhances cognitive memory
@ast
Pharmacological brake-release of mRNA translation enhances cognitive memory
@en
Pharmacological brake-release of mRNA translation enhances cognitive memory
@en-gb
Pharmacological brake-release of mRNA translation enhances cognitive memory
@nl
type
label
Pharmacological brake-release of mRNA translation enhances cognitive memory
@ast
Pharmacological brake-release of mRNA translation enhances cognitive memory
@en
Pharmacological brake-release of mRNA translation enhances cognitive memory
@en-gb
Pharmacological brake-release of mRNA translation enhances cognitive memory
@nl
prefLabel
Pharmacological brake-release of mRNA translation enhances cognitive memory
@ast
Pharmacological brake-release of mRNA translation enhances cognitive memory
@en
Pharmacological brake-release of mRNA translation enhances cognitive memory
@en-gb
Pharmacological brake-release of mRNA translation enhances cognitive memory
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
Pharmacological brake-release of mRNA translation enhances cognitive memory
@en
P2093
Arkady Khoutorsky
Avi Ashkenazi
Brian R Hearn
Byron Hann
Chris Wilson
Ciara M Gallagher
Karim Nader
Karine Gamache
Kenny K-H Ang
P2860
P304
P3181
P356
10.7554/ELIFE.00498
P407
P577
2013-01-01T00:00:00Z