Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. - Wikidata - wikimedia - TriplyDB

Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.

Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.

http://www.wikidata.org/entity/Q35590995

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Exploring Internal Ribosome Entry Sites as Therapeutic Targets Drosophila as an In Vivo Model for Human Neurodegenerative Disease Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice.Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult.Role of Endoplasmic Reticulum Stress in Learning and Memory Impairment and Alzheimer's Disease-Like Neuropathology in the PS19 and APPSwe Mouse Models of Tauopathy and Amyloidosis.CRISPulator: a discrete simulation tool for pooled genetic screens Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification.A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response.Next-generation libraries for robust RNA interference-based genome-wide screens.The Power of Sophisticated Phenotypic Screening and Modern Mechanism-of-Action Methods.An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response.Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine.Real-Time Imaging of Translation on Single mRNA Transcripts in Live Cells Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses eIF2α-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons.Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma.Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals.A small molecule targeting protein translation does not rescue spatial learning and memory deficits in the hAPP-J20 mouse model of Alzheimer's disease.Molecular Determinants of the Regulation of Development and Metabolism by Neuronal eIF2α Phosphorylation in Caenorhabditis elegans.Crystal structure of eIF2B and insights into eIF2-eIF2B interactions.The rise of proteostasis promoters.Endoplasmic reticulum proteostasis: a key checkpoint in cancer.Fine-tuning PERK signaling for neuroprotection.Mitochondrial dysfunction induces SESN2 gene expression through Activating Transcription Factor 4.Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells.Translation from the 5' untranslated region shapes the integrated stress response Modulating protein quality control Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound.A CRISPR Approach to Neurodegenerative Diseases.CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine.Elucidating drug targets and mechanisms of action by genetic screens in mammalian cells.Antagonism of the protein kinase R pathway in human cells by rhesus cytomegalovirus.A Unique ISR Program Determines Cellular Responses to Chronic Stress.CRISPR Approaches to Small Molecule Target Identification.STING-dependent translation inhibition restricts RNA virus replication.Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease.Driving Cancer Tumorigenesis and Metastasis Through UPR Signaling.Cell biology. Blocking stress response for better memory?EIF2B2 mutations in Vanishing White Matter Disease hyper- suppress translation and delay recovery during the integrated stress response.

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Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.

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Pharmacological dimerization a ...... he integrated stress response.

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Pharmacological dimerization a ...... he integrated stress response.

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Aaron S Mendez

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Adam R Renslo

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Billy W Newton

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Brian R Hearn

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Christopher S Fraser

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Edward L Tang

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Erik Verschueren

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Jeffrey R Johnson

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Masaaki Sokabe

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Nevan J Krogan

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P2860

Pharmacological brake-release of mRNA translation enhances cognitive memory

Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein

Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways

Cre-lox-regulated conditional RNA interference from transgenes

Sustained translational repression by eIF2α-P mediates prion neurodegeneration

Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1

eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation

eIF2B is a decameric guanine nucleotide exchange factor with a γ2ε2 tetrameric core.

eIF2γ mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation.

Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2.

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e07314

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10.7554/ELIFE.07314

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4

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Martin Kampmann

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25875391

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