Ubiquitin-proteasome system involvement in Huntington's disease
about
A dynamic interface between ubiquitylation and cAMP signalingBoth ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated.Reduced Levels of Proteasome Products in a Mouse Striatal Cell Model of Huntington's Disease.Identification of Genetic Factors that Modify Clinical Onset of Huntington's Disease.Comparison of mHTT Antibodies in Huntington's Disease Mouse Models Reveal Specific Binding Profiles and Steady-State Ubiquitin Levels with Disease DevelopmentDistinguishing aggregate formation and aggregate clearance using cell-based assays.Induced Pluripotent Stem Cells in Huntington's Disease: Disease Modeling and the Potential for Cell-Based Therapy.Spatiotemporal progression of ubiquitin-proteasome system inhibition after status epilepticus suggests protective adaptation against hippocampal injury.Long Term Aggresome Accumulation Leads to DNA Damage, p53-dependent Cell Cycle Arrest, and Steric Interference in Mitosis.Faulty splicing and cytoskeleton abnormalities in Huntington's disease.Proteolysis, synaptic plasticity and memory.Life and death in the trash heap: The ubiquitin proteasome pathway and UCHL1 in brain aging, neurodegenerative disease and cerebral Ischemia.The Ubiquitin Receptor ADRM1 Modulates HAP40-Induced Proteasome Activity.Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis.Protein misfolding in Dictyostelium: Using a freak of nature to gain insight into a universal problem.A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation.Co-expression Patterns between ATN1 and ATXN2 Coincide with Brain Regions Affected in Huntington's Disease.Cell-to-cell Transmission of Polyglutamine Aggregates in C. elegans.Spatiotemporal Proteomic Profiling of Huntington's Disease Inclusions Reveals Widespread Loss of Protein Function.An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition.Active Site Gate Dynamics Modulate the Catalytic Activity of the Ubiquitination Enzyme E2-25K.Preventing P-gp Ubiquitination Lowers Aβ Brain Levels in an Alzheimer's Disease Mouse Model.Huntington diseaseThe Role of Adenosine Tone and Adenosine Receptors in Huntington's Disease
P2860
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P2860
Ubiquitin-proteasome system involvement in Huntington's disease
description
2014 nî lūn-bûn
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2014 թուականին հրատարակուած գիտական յօդուած
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2014 թվականին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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name
Ubiquitin-proteasome system involvement in Huntington's disease
@ast
Ubiquitin-proteasome system involvement in Huntington's disease
@en
Ubiquitin-proteasome system involvement in Huntington's disease
@en-gb
Ubiquitin-proteasome system involvement in Huntington's disease
@nl
type
label
Ubiquitin-proteasome system involvement in Huntington's disease
@ast
Ubiquitin-proteasome system involvement in Huntington's disease
@en
Ubiquitin-proteasome system involvement in Huntington's disease
@en-gb
Ubiquitin-proteasome system involvement in Huntington's disease
@nl
prefLabel
Ubiquitin-proteasome system involvement in Huntington's disease
@ast
Ubiquitin-proteasome system involvement in Huntington's disease
@en
Ubiquitin-proteasome system involvement in Huntington's disease
@en-gb
Ubiquitin-proteasome system involvement in Huntington's disease
@nl
P2860
P3181
P356
P1476
Ubiquitin-proteasome system involvement in Huntington's disease
@en
P2093
Zaira Ortega
P2860
P3181
P356
10.3389/FNMOL.2014.00077
P407
P577
2014-01-01T00:00:00Z