about
Corticostriatal Dysfunction in Huntington's Disease: The BasicsLaquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease.Huntington’s disease blood and brain show a common gene expression pattern and share an immune signature with Alzheimer’s diseaseNeurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington's disease: a retrospective cohort analysisDelayed emergence of subdiffraction-sized mutant huntingtin fibrils following inclusion body formation.Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.HttQ111/+ model of Huntington's disease.Attenuated pupillary light responses and downregulation of opsin expression parallel decline in circadian disruption in two different mouse models of Huntington's diseaseDistinct cellular toxicity of two mutant huntingtin mRNA variants due to translation regulation.The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington's disease patientsFibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine coreMicroglial Activation in the Pathogenesis of Huntington's Disease.Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer.Polyglutamine Tract Expansion Increases S-Nitrosylation of Huntingtin and Ataxin-1.The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington diseaseA new Caenorhabditis elegans model of human huntingtin 513 aggregation and toxicity in body wall musclesImpaired TrkB Signaling Underlies Reduced BDNF-Mediated Trophic Support of Striatal Neurons in the R6/2 Mouse Model of Huntington's Disease.Cerebrospinal fluid total tau concentration predicts clinical phenotype in Huntington's disease.Psychogenic non-epileptic seizures in early Huntington's disease.Haplotype-based stratification of Huntington's disease.Mutant huntingtin is secreted via a late endosomal/lysosomal unconventional secretory pathway.Clinical Trials in Spinal and Bulbar Muscular Atrophy-Past, Present, and Future.AAV5-miHTT gene therapy demonstrates suppression of mutant huntingtin aggregation and neuronal dysfunction in a rat model of Huntington's disease.CRISPR Editing in Biological and Biomedical Investigation.Fifteen Years of Clinical Trials in Huntington's Disease: A Very Low Clinical Drug Development Success Rate.Antipsychotic drugs in Huntington's disease.Prospective Evaluation of Predictive DNA Testing for Huntington's Disease in a Large German Center.Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice.The global prevalence of Huntington's disease: a systematic review and discussion.Oxidative metabolism and Ca2+ handling in striatal mitochondria from YAC128 mice, a model of Huntington's disease.Dysregulation of Corticostriatal Connectivity in Huntington's Disease: A Role for Dopamine ModulationBackbone Engineering within a Latent β-Hairpin Structure to Design Inhibitors of Polyglutamine Amyloid Formation.Calcium signaling and molecular mechanisms underlying neurodegenerative diseases.Close encounters: Moving along bumps, breaks, and bubbles on expanded trinucleotide tracts.Crosstalk and Interplay between the Ubiquitin-Proteasome System and Autophagy.The targetable A1 Huntington disease haplotype has distinct Amerindian and European origins in Latin America.Huntington disease reduced penetrance alleles occur at high frequency in the general population.Polyglutamine expansion affects huntingtin conformation in multiple Huntington's disease models.miR-196a Enhances Neuronal Morphology through Suppressing RANBP10 to Provide Neuroprotection in Huntington's Disease.The Generation of Mouse and Human Huntington Disease iPS Cells Suitable for In vitro Studies on Huntingtin FunctionAxonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders
P2860
Q26738379-70D1A4EA-8C44-4340-8FB8-5A3BEE172300Q27316866-0B40122D-73BE-4D51-8FC3-DB0526BB9118Q29248581-9F0331C3-5FC5-45B0-BABA-63B587BBB5ECQ30224292-941EA81C-AE6F-426F-ADC7-5EA4A85C5B99Q30724979-CE97268F-5C80-43AC-8C71-0731967AA6DDQ30837903-F75EEBA8-8C14-4455-A8F0-94908F9363DAQ33640990-A5A5368C-359B-4404-B41A-2E7147087057Q33663833-F8E5BE3A-3B33-4BD8-A996-C50F0DDF5724Q33683726-88588A43-53A5-4034-AE4F-E547F27AF9EAQ33761247-38A9979A-C870-4002-8F05-605492C38F82Q33809556-085D1042-C497-42D6-B8F4-66076B10EDD6Q36043574-1E5381BE-8D8F-47D1-9181-74FBEA8F331FQ36141277-D884FEE1-28E4-445C-91D5-88CC705461B9Q36183832-90DF0491-9FD9-470D-AE0C-3A30CC875539Q36304420-A70BC470-E886-4E50-856D-266E64DC82B1Q36665616-6F928336-34AC-4E6E-81C9-70D278AD402CQ37316561-33D0E516-EC77-40CC-B8DD-C28CB6A888C7Q37471567-67F81902-FE22-46BA-A4B8-537AE5C43D3CQ38612630-90399AB9-949F-49B7-BBF6-7D42710BDFE2Q38618002-DDA8C0C2-23B9-4C71-B37B-777D4227F555Q38634370-ADBE0CBC-DC04-48A1-9743-B86563C09F7EQ38644645-24BC5640-CF95-41A1-9D6B-6F2FDE6BE708Q38645581-CBCEB1B9-C28A-4D30-8704-314617E56948Q38697132-41B38D5D-D3B4-47EE-9904-C0E906C2B846Q38830416-B15B2334-995C-4B5D-9969-C2860C00F258Q38865495-546752FD-7D4D-4004-881F-5413C2AC396EQ38893465-6D002849-9929-45A8-B366-283BB95929D9Q38923318-D73CC620-CA3A-4A8E-A516-0930BCA9AA51Q39035184-BECE40E4-B5AB-4FF8-9320-EAEAE1F3D162Q39041217-5446B21F-A4AA-429D-846B-ED87B3CC3821Q39093738-6BC19BEC-03BC-4321-824D-5921590CD735Q39152527-E8405692-E8A7-4F2F-B751-34ED0843B53AQ39424134-3AD7544A-52B4-467E-A663-179F43D4600AQ39457805-0D12F5B8-C0A9-4CD5-93F6-F9C0838DA19FQ40414168-DD0D6614-D2E8-4D95-8EE3-84BD00CD0136Q40686505-4C4C000B-81B8-42F8-9287-3AA2D7AD2BDFQ40985899-D8EBA924-FCB5-4A73-9C9C-021F472CFBE6Q41114302-EBFF9E85-13F8-451D-84B9-F87AF80CA920Q41334055-6B8043E7-49B0-46DB-85AD-8D52C6D569C3Q41475139-E2A0F06C-4F3B-4D85-8307-00C34988ECBB
P2860
description
наукова стаття, опублікована у квітні 2015
@uk
name
Huntington disease
@en
type
label
Huntington disease
@en
prefLabel
Huntington disease
@en
P2093
P2860
P50
P356
P1476
Huntington disease
@en
P2093
Edward J. Wild
Gillian P. Bates
Martha Nance
Rachael I. Scahill
Ray Dorsey
Ronald Wetzel
P2860
P2888
P356
10.1038/NRDP.2015.5
P577
2015-04-23T00:00:00Z