Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease
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Cholesterol homeostasis: a key to prevent or slow down neurodegenerationNaturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanismRapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous miceStronger is not always better: could a bodybuilding dietary supplement lead to ALS?mTOR is a key modulator of ageing and age-related diseaseAutophagy in ageing and ageing-associated diseasesFinding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging MoleculesInhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and BeyondNew Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of AutophagyMolecular Targets in Alzheimer's Disease: From Pathogenesis to TherapeuticsThe Function of Autophagy in Neurodegenerative DiseasesThe Concept of Hormesis in Cancer Therapy - Is Less More?Milk--A Nutrient System of Mammalian Evolution Promoting mTORC1-Dependent TranslationThe neurology of mTORDual roles for autophagy: degradation and secretion of Alzheimer's disease Aβ peptideErythropoietin: new directions for the nervous systemCutting through the complexities of mTOR for the treatment of strokeTargeting disease through novel pathways of apoptosis and autophagymTOR-dependent cell survival mechanismsAutophagy and neurodegenerationShedding new light on neurodegenerative diseases through the mammalian target of rapamycinTherapeutic targeting of autophagy in neurodegenerative and infectious diseasesDriving neural regeneration through the mammalian target of rapamycindnc-1/dynactin 1 knockdown disrupts transport of autophagosomes and induces motor neuron degenerationGenome-wide analysis of miRNA signature in the APPswe/PS1ΔE9 mouse model of alzheimer's diseaseTargeting the prodromal stage of Alzheimer's disease: bioenergetic and mitochondrial opportunitiesRas Homolog Enriched in Brain (Rheb) Enhances Apoptotic SignalingPotential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disordersACAT1/SOAT1 as a therapeutic target for Alzheimer's diseaseThe role of mTOR signaling in Alzheimer diseaseIntermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J MiceThe Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and AgingPim1 inhibition as a novel therapeutic strategy for Alzheimer's diseaseRapalogs and mTOR inhibitors as anti-aging therapeuticsA cell-penetrating ester of the neural metabolite lanthionine ketimine stimulates autophagy through the mTORC1 pathway: Evidence for a mechanism of action with pharmacological implications for neurodegenerative pathologiesRegulation of cardiac expression of the diabetic marker microRNA miR-29Cilostazol Modulates Autophagic Degradation of β-Amyloid Peptide via SIRT1-Coupled LKB1/AMPKα Signaling in Neuronal CellsMicropublications: a semantic model for claims, evidence, arguments and annotations in biomedical communicationsEnergy intake and exercise as determinants of brain health and vulnerability to injury and diseaseLeucine signaling in the pathogenesis of type 2 diabetes and obesity
P2860
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P2860
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease
description
2010 nî lūn-bûn
@nan
2010 թուականին հրատարակուած գիտական յօդուած
@hyw
2010 թվականին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Inhibition of mTOR by rapamyci ...... e model of Alzheimer's disease
@ast
Inhibition of mTOR by rapamyci ...... e model of Alzheimer's disease
@en
Inhibition of mTOR by rapamyci ...... e model of Alzheimer's disease
@en-gb
Inhibition of mTOR by rapamyci ...... e model of Alzheimer's disease
@nl
type
label
Inhibition of mTOR by rapamyci ...... e model of Alzheimer's disease
@ast
Inhibition of mTOR by rapamyci ...... e model of Alzheimer's disease
@en
Inhibition of mTOR by rapamyci ...... e model of Alzheimer's disease
@en-gb
Inhibition of mTOR by rapamyci ...... e model of Alzheimer's disease
@nl
altLabel
Inhibition of mTOR by Rapamyci ...... e Model of Alzheimer's Disease
@en
prefLabel
Inhibition of mTOR by rapamyci ...... e model of Alzheimer's disease
@ast
Inhibition of mTOR by rapamyci ...... e model of Alzheimer's disease
@en
Inhibition of mTOR by rapamyci ...... e model of Alzheimer's disease
@en-gb
Inhibition of mTOR by rapamyci ...... e model of Alzheimer's disease
@nl
P2093
P2860
P3181
P1433
P1476
Inhibition of mTOR by rapamyci ...... e model of Alzheimer's disease
@en
P2093
Arlan Richardson
Dale Bredesen
Matthew J Hart
Natalia Podlutskaya
Olivia Gorostiza
Patricia Spilman
Randy Strong
Veronica Galvan
P2860
P3181
P356
10.1371/JOURNAL.PONE.0009979
P407
P577
2010-01-01T00:00:00Z