Reconstruction of ancestral metabolic enzymes reveals molecular mechanisms underlying evolutionary innovation through gene duplication
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The Impact of Non-Enzymatic Reactions and Enzyme Promiscuity on Cellular Metabolism during (Oxidative) Stress ConditionsThe widespread role of non-enzymatic reactions in cellular metabolismConservation of Protein Structure over Four Billion YearsVestigialization of an Allosteric Switch: Genetic and Structural Mechanisms for the Evolution of Constitutive Activity in a Steroid Hormone ReceptorAn atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenasesSimilarities and differences in the biochemical and enzymological properties of the four isomaltases from Saccharomyces cerevisiae.Rapid bursts and slow declines: on the possible evolutionary trajectories of enzymesTangled up in two: a burst of genome duplications at the end of the Cretaceous and the consequences for plant evolutionThe natural history of molecular functions inferred from an extensive phylogenomic analysis of gene ontology dataGenetic Polymorphism in Wine Yeasts: Mechanisms and Methods for Its DetectionConvergence of Domain Architecture, Structure, and Ligand Affinity in Animal and Plant RNA-Binding Proteins.Duplication of a promiscuous transcription factor drives the emergence of a new regulatory network.Biophysics of protein evolution and evolutionary protein biophysicsEscherichia coli D-malate dehydrogenase, a generalist enzyme active in the leucine biosynthesis pathwayComputational design of a self-assembling symmetrical β-propeller protein.Reconstructed Ancestral Enzymes Impose a Fitness Cost upon Modern Bacteria Despite Exhibiting Favourable Biochemical Properties.The thermostability and specificity of ancient proteins.Toward more accurate ancestral protein genotype-phenotype reconstructions with the use of species tree-aware gene trees.Mutational studies on resurrected ancestral proteins reveal conservation of site-specific amino acid preferences throughout evolutionary history.Reconstructed ancestral Myo-inositol-3-phosphate synthases indicate that ancestors of the Thermococcales and Thermotoga species were more thermophilic than their descendants.Improving industrial yeast strains: exploiting natural and artificial diversity.Phenotypic evaluation of natural and industrial Saccharomyces yeasts for different traits desirable in industrial bioethanol production.Detecting functional divergence after gene duplication through evolutionary changes in posttranslational regulatory sequences.Evolution of new functions de novo and from preexisting genes.AAV ancestral reconstruction library enables selection of broadly infectious viral variants.Variable Glutamine-Rich Repeats Modulate Transcription Factor Activity.Resurrecting ancestral structural dynamics of an antiviral immune receptor: adaptive binding pocket reorganization repeatedly shifts RNA preference.The Zygosaccharomyces bailii transcription factor Haa1 is required for acetic acid and copper stress responses suggesting subfunctionalization of the ancestral bifunctional protein Haa1/Cup2.Increased rates of protein evolution and asymmetric deceleration after the whole-genome duplication in yeasts.Differential paralog divergence modulates genome evolution across yeast species.Origin of an ancient hormone/receptor couple revealed by resurrection of an ancestral estrogenGene Family Expansions in Aphids Maintained by Endosymbiotic and Nonsymbiotic TraitsAdaptation of the osmotolerant yeast Zygosaccharomyces rouxii to an osmotic environment through copy number amplification of FLO11D.Evolution of a Catalytic Mechanism.Mechanisms of transcription factor evolution in Metazoa.An integrated framework for discovery and genotyping of genomic variants from high-throughput sequencing experimentsThe functional importance of co-evolving residues in proteins.The protein invasion: a broad review on the origin of the translational system.Dynamics and constraints of enzyme evolution.Insights into molecular evolution from yeast genomics.
P2860
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P2860
Reconstruction of ancestral metabolic enzymes reveals molecular mechanisms underlying evolutionary innovation through gene duplication
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Reconstruction of ancestral me ...... ation through gene duplication
@ast
Reconstruction of ancestral me ...... ation through gene duplication
@en
Reconstruction of ancestral me ...... ation through gene duplication
@en-gb
Reconstruction of ancestral me ...... ation through gene duplication
@nl
type
label
Reconstruction of ancestral me ...... ation through gene duplication
@ast
Reconstruction of ancestral me ...... ation through gene duplication
@en
Reconstruction of ancestral me ...... ation through gene duplication
@en-gb
Reconstruction of ancestral me ...... ation through gene duplication
@nl
altLabel
Reconstruction of Ancestral Me ...... ation through Gene Duplication
@en
prefLabel
Reconstruction of ancestral me ...... ation through gene duplication
@ast
Reconstruction of ancestral me ...... ation through gene duplication
@en
Reconstruction of ancestral me ...... ation through gene duplication
@en-gb
Reconstruction of ancestral me ...... ation through gene duplication
@nl
P2093
P2860
P50
P3181
P1433
P1476
Reconstruction of ancestral me ...... ation through gene duplication
@en
P2093
Chris A Brown
Karin Voordeckers
Kevin Vanneste
P2860
P304
P3181
P356
10.1371/JOURNAL.PBIO.1001446
P407
P577
2012-01-01T00:00:00Z