about
Reconstruction of ancestral metabolic enzymes reveals molecular mechanisms underlying evolutionary innovation through gene duplicationThe Saccharomyces cerevisiae EHT1 and EEB1 genes encode novel enzymes with medium-chain fatty acid ethyl ester synthesis and hydrolysis capacity.Electrostatic similarities between protein and small molecule ligands facilitate the design of protein-protein interaction inhibitorsVirus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.Pharmacophore modelling as a virtual screening tool for the discovery of small molecule protein-protein interaction inhibitors.Fragment based drug design: from experimental to computational approaches.Computational design of a self-assembling symmetrical β-propeller protein.An integrated fragment based screening approach for the discovery of small molecule modulators of the VWF-GPIbα interaction.Mapping the binding interface between an HIV-1 inhibiting intrabody and the viral protein RevProtein interface pharmacophore mapping tools for small molecule protein: protein interaction inhibitor discovery.Rapid Conformational Fluctuations of Disordered HIV-1 Fusion Peptide in Solution.An optimized MM/PBSA virtual screening approach applied to an HIV-1 gp41 fusion peptide inhibitor.A rotation-translation invariant molecular descriptor of partial charges and its use in ligand-based virtual screening.In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2.Functional conservation of HIV-1 Gag: implications for rational drug design.Combining in silico and in cerebro approaches for virtual screening and pose prediction in SAMPL4.Identification of small peptides inhibiting the integrase-LEDGF/p75 interaction through targeting the cellular co-factor.Diversity oriented microwave-assisted synthesis of (-)-steganacin aza-analogues.Assay methods for small ubiquitin-like modifier (SUMO)-SUMO-interacting motif (SIM) interactions in vivo and in vitro using a split-luciferase complementation system.The discovery of novel human androgen receptor antagonist chemotypes using a combined pharmacophore screening procedure.His22 of TLXI plays a critical role in the inhibition of glycoside hydrolase family 11 xylanasesComputational design of symmetrical eight-bladed β-propeller proteinsComputational investigation of the HIV-1 Rev multimerization using molecular dynamics simulations and binding free energy calculationsIdentification and characterization of MEL-3, a novel AR antagonist that suppresses prostate cancer cell growthArtificial β-propeller protein-based hydrolases
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Arnout Voet
@ast
Arnout Voet
@en
Arnout Voet
@es
Arnout Voet
@nl
type
label
Arnout Voet
@ast
Arnout Voet
@en
Arnout Voet
@es
Arnout Voet
@nl
prefLabel
Arnout Voet
@ast
Arnout Voet
@en
Arnout Voet
@es
Arnout Voet
@nl
P106
P1153
24336622700
P31
P496
0000-0002-3329-2703