A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease
about
Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL KinasePhosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture.Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's diseaseDrug combination therapy increases successful drug repositioning.Targeting Fyn Kinase in Alzheimer's Disease.Treatment of Alzheimer's Disease: The Legacy of the Cholinergic Hypothesis, Neuroplasticity, and Future Directions.Crossing the Blood-Brain Barrier: Recent Advances in Drug Delivery to the Brain.Epileptic activity in Alzheimer's disease: causes and clinical relevance.Oligomers of Amyloid β Prevent Physiological Activation of the Cellular Prion Protein-Metabotropic Glutamate Receptor 5 Complex by Glutamate in Alzheimer Disease.Uncontrolled SFK-mediated protein trafficking in prion and Alzheimer's diseaseTau Proteins and Tauopathies in Alzheimer's Disease.Recent advances in phosphoproteomics and application to neurological diseases.Role of the Fyn-PKCδ signaling in SE-induced neuroinflammation and epileptogenesis in experimental models of temporal lobe epilepsy.Synaptotoxic Signaling by Amyloid Beta Oligomers in Alzheimer's Disease Through Prion Protein and mGluR5.An Overview on the Clinical Development of Tau-Based Therapeutics.A novel computational approach for drug repurposing using systems biology.The Kinase Fyn As a Novel Intermediate in L-DOPA-Induced Dyskinesia in Parkinson's Disease.Targeting the intracellular signaling "STOP" and "GO" pathways for the treatment of alcohol use disorders.
P2860
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P2860
A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease
description
2015 nî lūn-bûn
@nan
2015 թուականին հրատարակուած գիտական յօդուած
@hyw
2015 թվականին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
A phase Ib multiple ascending ...... atinib) in Alzheimer's disease
@ast
A phase Ib multiple ascending ...... atinib) in Alzheimer's disease
@en
A phase Ib multiple ascending ...... atinib) in Alzheimer's disease
@en-gb
A phase Ib multiple ascending ...... atinib) in Alzheimer's disease
@nl
type
label
A phase Ib multiple ascending ...... atinib) in Alzheimer's disease
@ast
A phase Ib multiple ascending ...... atinib) in Alzheimer's disease
@en
A phase Ib multiple ascending ...... atinib) in Alzheimer's disease
@en-gb
A phase Ib multiple ascending ...... atinib) in Alzheimer's disease
@nl
prefLabel
A phase Ib multiple ascending ...... atinib) in Alzheimer's disease
@ast
A phase Ib multiple ascending ...... atinib) in Alzheimer's disease
@en
A phase Ib multiple ascending ...... atinib) in Alzheimer's disease
@en-gb
A phase Ib multiple ascending ...... atinib) in Alzheimer's disease
@nl
P2093
P2860
P1476
A phase Ib multiple ascending ...... atinib) in Alzheimer's disease
@en
P2093
Adam C Kaufman
Allison F Wagner
Anthony J Koleske
Brian J Rosenberg
Christopher H van Dyck
Garrett S Bowen
Haakon B Nygaard
Kewei Chen
Kurt A Strittmatter
Martha G MacAvoy
P2860
P2888
P356
10.1186/S13195-015-0119-0
P407
P577
2015-01-01T00:00:00Z
P5875
P6179
1046714984