Alzheimer's disease brain-derived amyloid-β-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein
about
A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's diseaseMetabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion proteinAmyloid-β-Induced Dysregulation of AMPA Receptor TraffickingAmyloid-β Receptors: The Good, the Bad, and the Prion ProteinUnfolded Protein Response and Macroautophagy in Alzheimer's, Parkinson's and Prion DiseasesAlzheimer's Disease: Mechanism and Approach to Cell TherapyAmyloid-β induced signaling by cellular prion protein and Fyn kinase in Alzheimer diseaseHijacking PrP(c)-dependent signal transduction: when prions impair Aβ clearanceInsoluble cellular prion protein and its association with prion and Alzheimer diseasesAmyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's diseaseAmyloid-β and proinflammatory cytokines utilize a prion protein-dependent pathway to activate NADPH oxidase and induce cofilin-actin rods in hippocampal neuronsThe dendritic hypothesis for Alzheimer's disease pathophysiology.Immunotherapeutic approaches for Alzheimer's diseaseAlzheimer's disease and prion proteinFunctions of the cellular prion protein, the end of Moore's law, and Ockham's razor theoryAlzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons.Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1Brain immune interactions and air pollution: macrophage inhibitory factor (MIF), prion cellular protein (PrP(C)), Interleukin-6 (IL-6), interleukin 1 receptor antagonist (IL-1Ra), and interleukin-2 (IL-2) in cerebrospinal fluid and MIF in serum diffAlzheimer brain-derived amyloid β-protein impairs synaptic remodeling and memory consolidation.The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative DiseasesAmyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies.The intersection of amyloid beta and tau at synapses in Alzheimer's diseaseCellular prion protein expression is not regulated by the Alzheimer's amyloid precursor protein intracellular domain.Plasma prion protein concentration and progression of Alzheimer disease.Therapeutic molecules and endogenous ligands regulate the interaction between brain cellular prion protein (PrPC) and metabotropic glutamate receptor 5 (mGluR5).Amyloid-beta: a crucial factor in Alzheimer's disease.Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo.Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.Novel immunological approaches for the treatment of Alzheimer's disease.Sod1 deficiency reduces incubation time in mouse models of prion diseaseIntravenous immunglobulin binds beta amyloid and modifies its aggregation, neurotoxicity and microglial phagocytosis in vitro.High resolution imaging study of interactions between the 37 kDa/67 kDa laminin receptor and APP, beta-secretase and gamma-secretase in Alzheimer's disease.The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease.Soluble Aβ oligomer production and toxicity.Prion protein at the crossroads of physiology and disease.Aβ neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptorsCellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death.Iron is a specific cofactor for distinct oxidation- and aggregation-dependent Aβ toxicity mechanisms in a Drosophila model.Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models.The aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species.
P2860
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P2860
Alzheimer's disease brain-derived amyloid-β-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein
description
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2011
@ast
scientific journal article
@en
wetenschappelijk artikel (gepubliceerd op 2011/05/18)
@nl
wissenschaftlicher Artikel
@de
наукова стаття, опублікована в травні 2011
@uk
مقالة علمية نشرت في 18-5-2011 حول موضوع: دماغ
@ar
name
Alzheimer's disease brain-deri ...... rgeting cellular prion protein
@ast
Alzheimer's disease brain-deri ...... rgeting cellular prion protein
@en
type
label
Alzheimer's disease brain-deri ...... rgeting cellular prion protein
@ast
Alzheimer's disease brain-deri ...... rgeting cellular prion protein
@en
prefLabel
Alzheimer's disease brain-deri ...... rgeting cellular prion protein
@ast
Alzheimer's disease brain-deri ...... rgeting cellular prion protein
@en
P2093
P921
P1476
Alzheimer's disease brain-deri ...... rgeting cellular prion protein
@en
P2093
Andrew E Barry
Dominic M Walsh
Igor Klyubin
Jessica M Mc Donald
Michael A Farrell
Michael Scott
P304
P356
10.1523/JNEUROSCI.6500-10.2011
P407
P577
2011-05-01T00:00:00Z