about
P688
A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signalingAn alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitorGeneration of amyloid-β is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrinPresenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation.The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretaseAmyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavageIdentification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid betaIsolation and characterization of novel presenilin binding proteinA presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domainInteraction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilinsDeficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory tracesSkeletal and CNS defects in Presenilin-1-deficient micePresenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiencyRelease of a membrane-bound death domain by gamma-secretase processing of the p75NTR homolog NRADDPresenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activitiesLysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutationsNeurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutationPresenilin 1 in migration and morphogenesis in the central nervous systemMice lacking both presenilin genes exhibit early embryonic patterning defectsErlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide productionNotch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogensMutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implicationPresenilin 1 is required for maturation and cell surface accumulation of nicastrinDegradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neuronsForebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptakeAlzheimer's presenilin 1 mutations impair kinesin-based axonal transportNotch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosisAltered morphological and electrophysiological properties of Cajal-Retzius cells in cerebral cortex of embryonic Presenilin-1 knockout micePresenilin 1 is required for Notch1 and DII1 expression in the paraxial mesodermPresenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expressionEnvironment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient miceCapacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor proteinImpaired cell cycle control of neuronal precursor cells in the neocortical primordium of presenilin-1-deficient micePresenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations
P921
Q24294366-604758D5-8322-4270-8D1C-425048E73DF7Q24301886-D7CE7D21-85F7-4DA7-9BB2-4A8A8C71948AQ24302464-11361C66-48E7-43B1-A07F-C2718F871B7AQ24306299-4DC4C6AA-3853-480D-88E3-0A6A4FF14BD4Q24317272-F49C6E4A-8891-4A35-841F-3A53CBB89956Q24338484-22EC3335-8341-41B1-8D25-A60472D15900Q24541447-469DA468-C92F-4B54-875A-43FDF7551B42Q24670362-3F5E3998-7B41-48B0-926F-1ED7E73A8DBDQ24672149-A927DD4E-9E65-492B-BCB6-2006DECF3C6FQ27014952-5B6B8649-6864-44B4-A160-1C6723419A7CQ28118077-DCA5B040-395B-4913-80CA-4FEC290B5C4CQ28138326-886E3420-FF11-424E-A013-5176F6BE9916Q28141707-34F93878-0618-4C7E-9026-3A69AB5C53C9Q28206918-ECBBFCC7-E4DE-4773-B990-C3171F9E0523Q28209723-3691DFA3-4A7F-4F98-AF66-E694C1FCCFCEQ28238795-89163B21-D604-4329-8E51-263135DD57E1Q28505078-EB8E22EF-9DA9-4F2C-9D02-D05A9888EA73Q28506272-4C9FE804-0445-48CA-AAF4-B9C957F6E631Q28506461-4D87BE1D-C1E5-4C9B-B2EB-E4DAD36857C6Q28506710-1D59EF39-3EC2-40CE-9A98-A12CA91009F8Q28506810-F204834C-8A0D-4B63-ACB5-F77FB3CF300CQ28508941-69090B05-67D4-4989-AB73-09F1B1C6217DQ28508946-443FBB93-5E22-4315-A286-A3E243C04BF2Q28509121-08222213-BB6F-432B-85B0-9F42A31FA580Q28509751-1979B1B8-B35F-444C-9843-33FF8AFD0984Q28510031-AD906030-9236-4DAF-8664-21B0D5079849Q28510523-46A131F9-7F0E-40D5-9AA5-B3522DB0FBC8Q28511388-34AC13BD-2B1A-40B7-9284-5BBDE7B9A40CQ28511413-9568C6A6-4310-42D8-B298-640D9E4B6BA2Q28511563-0C436E74-782A-490F-8C94-F53B318D9E4FQ28512320-A8E5075D-F805-4879-807A-0CB41EA0B9CFQ28512806-B5BC3B5B-D5B9-48D0-80BD-656EB3A8E775Q28512968-BE66B882-5CB9-43EF-BF83-6C9E34B056D5Q28585594-4942D3AD-75B2-4E11-A769-0F47FB248D4BQ28585864-29A6A57E-971A-454C-9F1D-5521D4BE0A25Q28586083-59916645-0F05-4924-AA63-910244550242Q28586098-6E1BF276-41D8-4CB9-9949-1C5DD5C227C6Q28586113-0CE6BA69-1D7A-4536-B700-D8A5B4FE267BQ28586910-A72FA76B-3FD6-481E-86BA-4BD2CE60B3ECQ28587440-5EFAFCFB-4706-406D-8D1E-0AE4FAADF6E9
P921
description
mammalian protein found in Mus musculus
@en
protein
@id
proteinë
@sq
proteïne in Presenilin 1
@nl
protèin
@ace
بروتين في فأر المنازل
@ar
name
Presenilin 1
@en
Presenilin 1
@nl
type
label
Presenilin 1
@en
Presenilin 1
@nl
altLabel
Protein S182
@en
Psen1
@en
presenilin-1
@en
prefLabel
Presenilin 1
@en
Presenilin 1
@nl
P680
P681
P682
P352
P637
P31
P352
P637
NP_001349200