about
P688
Genomic instability in laminopathy-based premature agingHeterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient miceBiochemical studies of Zmpste24-deficient miceZMPSTE24 defends against influenza and other pathogenic virusesPrelamin A and lamin A appear to be dispensable in the nuclear lamina.Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient miceHIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells.Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations.Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria.Premature aging in mice activates a systemic metabolic response involving autophagy induction.Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53.Cartilage oligomeric matrix protein prevents vascular aging and vascular smooth muscle cells senescence.Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease
P921
Q28258404-32FDB046-7C18-46A1-AEA2-FF0A2C4BD3A7Q28505849-76C0A9B0-5278-4ED7-B684-8247C980C24BQ28588204-B9C12DE9-26C8-4971-87D9-43263F221E82Q29365364-9AEE57BB-CB77-4592-A5C4-AD880D9D6094Q34416396-892C0599-F540-4D6B-8C50-DE289EE857E2Q34440150-92F4BA76-4F43-45B0-BE4E-56E45D2BF944Q35134204-30A3883B-586C-4C83-8250-010AFE523885Q35941280-2AE17D83-E3BE-42A8-953B-5C3F2EB0DDC5Q37469701-40EF43D7-420F-476A-A111-DE8195D081F0Q42142108-8A12B817-353F-42BB-9DD4-438AB14A97AAQ42278285-5B21975C-837A-4CCB-95FF-DDFC973241B5Q42435408-E3D44D6D-97F7-41D2-954E-03F7D61413B6Q42762768-10C81E12-B69A-4E2F-9417-7D1A683CAA5DQ51589066-B822EE4D-750D-4FFA-9D53-AEB9A53CA057Q52545724-1EDF571C-1921-406F-AB84-0F009978406BQ57082627-EA8484EF-2F21-4A9E-A9D0-ABFFDE756988
P921
description
mammalian protein found in Mus musculus
@en
protein
@id
proteinë
@sq
proteïne in Zinc metallopeptidase, STE24
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protèin
@ace
بروتين في فأر المنازل
@ar
name
Zinc metallopeptidase, STE24
@en
Zinc metallopeptidase, STE24
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type
label
Zinc metallopeptidase, STE24
@en
Zinc metallopeptidase, STE24
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altLabel
CAAX prenyl protease 1 homolog
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FACE-1
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Farnesylated proteins-converting enzyme 1
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Zmpste24
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farnesylated-proteins converting enzyme 1
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prenyl protein-specific endoprotease 1
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zinc metallopeptidase, STE24 homolog
@en
zinc metalloproteinase Ste24 homolog
@en
zinc metalloproteinase, STE24 homolog
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prefLabel
Zinc metallopeptidase, STE24
@en
Zinc metallopeptidase, STE24
@nl
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