Humanin: a novel central regulator of peripheral insulin action
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Humanin, a cytoprotective peptide, is expressed in carotid atherosclerotic [corrected] plaques in humansThe emerging role of the mitochondrial-derived peptide humanin in stress resistanceAcute humanin therapy attenuates myocardial ischemia and reperfusion injury in miceHumanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient miceHumanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stressMitochondria and cardiovascular agingAntiapoptotic factor humanin is expressed in normal and tumoral pituitary cells and protects them from TNF-α-induced apoptosisMOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolismThe mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistanceA humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic miceSH3-binding protein 5 mediates the neuroprotective effect of the secreted bioactive peptide humanin by inhibiting c-Jun NH2-terminal kinaseHumanin Derivatives Inhibit Necrotic Cell Death in Neurons.Mitochondrial stress signaling in longevity: a new role for mitochondrial function in agingHumanin protects cortical neurons from ischemia and reperfusion injury by the increased activity of superoxide dismutase.IGF-I regulates the age-dependent signaling peptide humanin.Humanin: a harbinger of mitochondrial-derived peptides?Mangiferin stimulates carbohydrate oxidation and protects against metabolic disorders induced by high-fat diets.Diminished mTOR signaling: a common mode of action for endocrine longevity factors.Weight loss and incident dementia in elderly Yoruba Nigerians: a 10-year follow-up study.Humanin and age-related diseases: a new link?Humanin binds MPP8: mapping interaction sites of the peptide and protein.Central effects of humanin on hepatic triglyceride secretion.The Potent Humanin Analogue (HNG) Protects Germ Cells and Leucocytes While Enhancing Chemotherapy-Induced Suppression of Cancer Metastases in Male Mice.Dissecting the Mechanisms Underlying Unusually Successful Human Health Span and Life Span.Central insulin-like growth factor-1 (IGF-1) restores whole-body insulin action in a model of age-related insulin resistance and IGF-1 decline.Secreted calmodulin-like skin protein inhibits neuronal death in cell-based Alzheimer's disease models via the heterotrimeric Humanin receptorHumanin: a mitochondrial signaling peptide as a biomarker for impaired fasting glucose-related oxidative stress.Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers.Circulating humanin levels are associated with preserved coronary endothelial functionPharmacokinetics and tissue distribution of humanin and its analogues in male rodents.Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell.Comparison between surrogate indexes of insulin sensitivity/resistance and hyperinsulinemic euglycemic clamp estimates in rats.The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus.Humanin skeletal muscle protein levels increase after resistance training in men with impaired glucose metabolism.Tert-buthylhydroquinone pre-conditioning exerts dual effects in old female rats exposed to 3-nitropropionic acid.Effects of humanin on experimental colitis induced by 2,4,6-trinitrobenzene sulphonic acid in rats.Neurodegenerative disease and obesity: what is the role of weight loss and bariatric interventions?The emergence of the mitochondrial genome as a partial regulator of nuclear function is providing new insights into the genetic mechanisms underlying age-related complex disease.Protective effects of Humanin and calmodulin-like skin protein in Alzheimer's disease and broad range of abnormalities.The Mitochondrial-Derived Peptides, HumaninS14G and Small Humanin-like Peptide 2, Exhibit Chaperone-like Activity
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P2860
Humanin: a novel central regulator of peripheral insulin action
description
2009 nî lūn-bûn
@nan
2009 թուականին հրատարակուած գիտական յօդուած
@hyw
2009 թվականին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Humanin: a novel central regulator of peripheral insulin action
@ast
Humanin: a novel central regulator of peripheral insulin action
@en
Humanin: a novel central regulator of peripheral insulin action
@en-gb
Humanin: a novel central regulator of peripheral insulin action
@nl
type
label
Humanin: a novel central regulator of peripheral insulin action
@ast
Humanin: a novel central regulator of peripheral insulin action
@en
Humanin: a novel central regulator of peripheral insulin action
@en-gb
Humanin: a novel central regulator of peripheral insulin action
@nl
altLabel
Humanin: A Novel Central Regulator of Peripheral Insulin Action
@en
prefLabel
Humanin: a novel central regulator of peripheral insulin action
@ast
Humanin: a novel central regulator of peripheral insulin action
@en
Humanin: a novel central regulator of peripheral insulin action
@en-gb
Humanin: a novel central regulator of peripheral insulin action
@nl
P2093
P2860
P3181
P1433
P1476
Humanin: a novel central regulator of peripheral insulin action
@en
P2093
Aruna Poduval
Christoph Buettner
David Hwang
Derek M Huffman
Francine H Einstein
Laura J Cobb
Lingguang Cui
Nir Barzilai
Radhika H Muzumdar
Sigal Fishman
P2860
P3181
P356
10.1371/JOURNAL.PONE.0006334
P407
P577
2009-01-01T00:00:00Z