about
P688
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adductsThe cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1.Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genesTrex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease.Filamin-A regulates neutrophil uropod retraction through RhoA during chemotaxis.Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease.Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis.Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune ActivationActivation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseasesIFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication.Early onset of autoimmune disease by the retroviral integrase inhibitor raltegravir.Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism.Lack of Trex1 Causes Systemic Autoimmunity despite the Presence of Antiretroviral Drugs.Immunostimulatory Endogenous Nucleic Acids Drive the Lesional Inflammation in Cutaneous Lupus Erythematosus.The exonuclease Trex1 restrains macrophage proinflammatory activation.Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage.Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing.
P921
Q24337520-F1DD1EEC-0433-4808-9AA3-E2495630FE19Q34140181-112C9CC6-B7D9-4C9F-8595-60A9EFCA1363Q34312364-C529B9A9-DA03-4E94-B1FC-98DF71B516CEQ34719398-44756CD7-1A05-49A2-840D-B1F1161DFD45Q35036887-B6A5F613-46DB-425D-B8C2-A4F93C2ED757Q35549308-C6309D78-21B2-4530-A56D-7D8CD05185E3Q35663520-E6F3D6A7-65DB-4523-8C9C-D2302C377B73Q36073324-57A4C5C4-6ACA-49F7-B45A-D03727E49BAAQ36207338-D4DE397E-0741-4048-A7CC-E55C112C5CCEQ37353206-76876D67-BD15-4B54-9AA2-9CDC969BCE29Q37469579-B1C9453F-1153-4A83-9BF4-4B8A101174D4Q37612521-C04C38A1-DB1E-4ADC-BC65-DDACB6381035Q38611198-4375AA73-5ACC-4299-BB26-FBD961779081Q38738353-977BB71D-4971-4F63-9298-C31763D09B5AQ39064224-FE32E123-6DA7-4750-A11A-6F9E4FAA415CQ39698684-9C770E49-E3CA-4FD2-A200-4930646DFBDFQ44535307-DCB77D67-D83B-4E6B-B411-D5EBBFF972ED
P921
description
mammalian protein found in Mus musculus
@en
protein
@id
proteinë
@sq
proteïne in Three prime repair exonuclease 1
@nl
protèin
@ace
بروتين في فأر المنازل
@ar
name
Three prime repair exonuclease 1
@en
Three prime repair exonuclease 1
@nl
type
label
Three prime repair exonuclease 1
@en
Three prime repair exonuclease 1
@nl
altLabel
3'-5' exonuclease TREX1
@en
DNase III
@en
Trex1
@en
three prime exonuclease 1
@en
three-prime repair exonuclease 1
@en
trophoblast expressed 1
@en
prefLabel
Three prime repair exonuclease 1
@en
Three prime repair exonuclease 1
@nl
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NP_001012236
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ENSMUSP00000050971
ENSMUSP00000107684