The lipid phosphatase activity of PTEN is critical for its tumor supressor function
about
Human PIR1 of the protein-tyrosine phosphatase superfamily has RNA 5'-triphosphatase and diphosphatase activitiesThe tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal regionInteraction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinaseEvidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2Phosphorylation of the PTEN tail regulates protein stability and functionMyotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphatePTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein functionProapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and AktFinding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chipsPTEN inhibits BMI1 function independently of its phosphatase activityA comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromesSPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancerDistinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins.PTEN function: how normal cells control it and tumour cells lose itThe PI3K-PDK1 connection: more than just a road to PKBIntegration of the extranuclear and nuclear actions of estrogenDeficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulationRapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cellsAnalysis of the genome to personalize therapy for melanomaProtein kinases and phosphatases in the control of cell fateA clinical scoring system for selection of patients for PTEN mutation testing is proposed on the basis of a prospective study of 3042 probandsProtean PTEN: form and functionProtein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transductionThe tuberous sclerosis complexThe PI3K pathway as drug target in human cancerThe ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localizationRegulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathwayCritical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformationPtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migrationThe Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnoverMolecular responses to hypoxia in tumor cellsLoss of cellular adhesion to matrix induces p53-independent expression of PTEN tumor suppressorThe in vitro effect of gefitinib ('Iressa') alone and in combination with cytotoxic chemotherapy on human solid tumoursRole of Redox Status in Development of GlioblastomaMedical treatment for gastro-entero-pancreatic neuroendocrine tumoursCurrent understanding of metformin effect on the control of hyperglycemia in diabetesThe associations between Parkinson's disease and cancer: the plot thickensCellular biochemistry methods for investigating protein tyrosine phosphatasesPI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasms
P2860
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P2860
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
description
1998 nî lūn-bûn
@nan
1998 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
@ast
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
@en
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
@en-gb
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
@nl
type
label
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
@ast
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
@en
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
@en-gb
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
@nl
prefLabel
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
@ast
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
@en
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
@en-gb
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
@nl
P2093
P2860
P921
P3181
P356
P1476
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
@en
P2093
B A Hemmings
C P Downes
J P Stolarov
J Van der Kaay
P2860
P304
13513-13518
P3181
P356
10.1073/PNAS.95.23.13513
P407
P577
1998-11-01T00:00:00Z