Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues
about
VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis.The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cellsCaveolin-1 plays a crucial role in inhibiting neuronal differentiation of neural stem/progenitor cells via VEGF signaling-dependent pathwayPhosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptorsA heterogeneous in vitro three dimensional model of tumour-stroma interactions regulating sprouting angiogenesisGeneration of FGF reporter transgenic zebrafish and their utility in chemical screens.Phosphorylated KDR can be located in the nucleus of neoplastic cells.Sck is expressed in endothelial cells and participates in vascular endothelial growth factor-induced signaling.A ligand-independent VEGFR2 signaling pathway limits angiogenic responses in diabetes.Vascular endothelial growth factor receptor 2 (VEGFR-2) signalling activity in paediatric pilocytic astrocytoma is restricted to tumour endothelial cells.Automated image-based phenotypic analysis in zebrafish embryos.Molecular diversity of VEGF-A as a regulator of its biological activity.Development and strategies of VEGFR-2/KDR inhibitors.Leucine motif-dependent tyrosine autophosphorylation of type III receptor tyrosine kinases.Exploring novel KDR inhibitors based on pharmaco-informatics methodology.Kinase insert domain-containing receptor kinase inhibitors as anti-angiogenic agents.Antiangiogenic agents targeting vascular endothelial growth factor and its receptors in clinical development.Microtubules coordinate VEGFR2 signaling and sorting.Cancer-risk module identification and module-based disease risk evaluation: a case study on lung cancer.VEGFA family isoforms regulate spermatogonial stem cell homeostasis in vivoThe role of VEGF receptors in angiogenesis; complex partnershipsThe role of β-adrenergic receptor signaling in the proliferation of hemangioma-derived endothelial cellsProlonged blockade of VEGF receptors does not damage retinal photoreceptors or ganglion cells.Signal transduction in vasculogenesis and developmental angiogenesisVascular endothelial growth factors: multitasking functionality in metabolism, health and disease.Caveolin-1 regulates VEGF-stimulated angiogenic activities in prostate cancer and endothelial cells.Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones.The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation.VEGF-A/VEGFR2 signaling network in endothelial cells relevant to angiogenesis.Src kinases mediate VEGFR2 transactivation by the osteostatin domain of PTHrP to modulate osteoblastic function.Tyrosine phosphorylation of the vascular endothelial-growth-factor receptor-2 (VEGFR-2) is modulated by Rho proteins.Sinusoid development and morphogenesis may be stimulated by VEGF-Flk-1 signaling during fetal mouse liver development.The presence of a single tyrosine residue at the carboxyl domain of vascular endothelial growth factor receptor-2/FLK-1 regulates its autophosphorylation and activation of signaling molecules.ERK phosphorylation is linked to VEGFR2 expression and Ets-2 phosphorylation in breast cancer and is associated with tamoxifen treatment resistance and small tumours with good prognosis.VEGFR2 autophosphorylatesPharmacophore based 3D-QSAR modeling and free energy analysis of VEGFR-2 inhibitors.Signal transduction induced in endothelial cells by growth factor receptors involved in angiogenesis.
P2860
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P2860
Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues
description
1999 nî lūn-bûn
@nan
1999 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մարտին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Vascular endothelial growth fa ...... ivation loop tyrosine residues
@ast
Vascular endothelial growth fa ...... ivation loop tyrosine residues
@en
Vascular endothelial growth fa ...... ivation loop tyrosine residues
@en-gb
Vascular endothelial growth fa ...... ivation loop tyrosine residues
@nl
type
label
Vascular endothelial growth fa ...... ivation loop tyrosine residues
@ast
Vascular endothelial growth fa ...... ivation loop tyrosine residues
@en
Vascular endothelial growth fa ...... ivation loop tyrosine residues
@en-gb
Vascular endothelial growth fa ...... ivation loop tyrosine residues
@nl
prefLabel
Vascular endothelial growth fa ...... ivation loop tyrosine residues
@ast
Vascular endothelial growth fa ...... ivation loop tyrosine residues
@en
Vascular endothelial growth fa ...... ivation loop tyrosine residues
@en-gb
Vascular endothelial growth fa ...... ivation loop tyrosine residues
@nl
P2093
P2860
P921
P356
P1476
Vascular endothelial growth fa ...... ivation loop tyrosine residues
@en
P2093
A J Tebben
K A Thomas
R L Kendall
R W Hungate
R Z Rutledge
P2860
P304
P356
10.1074/JBC.274.10.6453
P407
P577
1999-03-05T00:00:00Z