Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism
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Functional analysis of H-Ryk, an atypical member of the receptor tyrosine kinase familyVascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residuesTransformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activationAsymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cellsUbiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosisNedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and functionThe selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding siteTyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formationThe crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition.Fibroblast growth factor-2 binds to small heparin-derived oligosaccharides and stimulates a sustained phosphorylation of p42/44 mitogen-activated protein kinase and proliferation of rat mammary fibroblastsCell signaling by receptor tyrosine kinasesEnhanced signaling and morphological transformation by a membrane-localized derivative of the fibroblast growth factor receptor 3 kinase domainActivation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loopCrystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252aA novel mutation in FGFR3 causes camptodactyly, tall stature, and hearing loss (CATSHL) syndromeDigenic mutations account for variable phenotypes in idiopathic hypogonadotropic hypogonadismImpaired FGF signaling contributes to cleft lip and palateCrystal structure of a conformation-selective casein kinase-1 inhibitorCrystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanismStructure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitorStructural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptorA Molecular Brake in the Kinase Hinge Region Regulates the Activity of Receptor Tyrosine KinasesStructural basis for reduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition and activationA crystallographic snapshot of tyrosine trans-phosphorylation in actionDiscovery of Novel Fibroblast Growth Factor Receptor 1 Kinase Inhibitors by Structure-Based Virtual ScreeningA Novel Mode of Protein Kinase Inhibition Exploiting Hydrophobic Motifs of Autoinhibited Kinases: DISCOVERY OF ATP-INDEPENDENT INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTORAssessing the range of kinase autoinhibition mechanisms in the insulin receptor familyStructural Mimicry of A-Loop Tyrosine Phosphorylation by a Pathogenic FGF Receptor 3 MutationStructure of FGFR3 Transmembrane Domain Dimer: Implications for Signaling and Human PathologiesDesign, synthesis and biological evaluation of novel FGFR inhibitors bearing an indazole scaffoldTyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42Fibroblast growth factor signaling in Caenorhabditis elegansMutation of a Shc binding site tyrosine residue in ErbB3/HER3 blocks heregulin-dependent activation of mitogen-activated protein kinaseMolecular mechanisms of fibroblast growth factor signaling in physiology and pathologyGenomic screening of fibroblast growth-factor receptor 2 reveals a wide spectrum of mutations in patients with syndromic craniosynostosisDefective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasiaTissue concentration of transforming growth factor beta1 and basic fibroblast growth factor in skin wounds created with a CO2 laser and scalpel: a comparative experimental study, using an animal model of skin resurfacingEffect of transmembrane and kinase domain mutations on fibroblast growth factor receptor 3 chimera signaling in PC12 cells. A model for the control of receptor tyrosine kinase activationPhosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors
P2860
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P2860
Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism
description
1996 nî lūn-bûn
@nan
1996 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Structure of the FGF receptor ...... novel autoinhibitory mechanism
@ast
Structure of the FGF receptor ...... novel autoinhibitory mechanism
@en
Structure of the FGF receptor ...... novel autoinhibitory mechanism
@nl
type
label
Structure of the FGF receptor ...... novel autoinhibitory mechanism
@ast
Structure of the FGF receptor ...... novel autoinhibitory mechanism
@en
Structure of the FGF receptor ...... novel autoinhibitory mechanism
@nl
prefLabel
Structure of the FGF receptor ...... novel autoinhibitory mechanism
@ast
Structure of the FGF receptor ...... novel autoinhibitory mechanism
@en
Structure of the FGF receptor ...... novel autoinhibitory mechanism
@nl
P2093
P3181
P1433
P1476
Structure of the FGF receptor ...... novel autoinhibitory mechanism
@en
P2093
J Schlessinger
M Mohammadi
S R Hubbard
P304
P3181
P356
10.1016/S0092-8674(00)80131-2
P407
P577
1996-08-23T00:00:00Z