Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control
about
RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint controlBRCA2 and homologous recombinationPurified human BRCA2 stimulates RAD51-mediated recombinationA mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressorCDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repairValine 1532 of human BRC repeat 4 plays an important role in the interaction between BRCA2 and RAD51Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeatsInsights into DNA recombination from the structure of a RAD51-BRCA2 complexThe BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51Rec2 interplay with both Brh2 and Rad51 balances recombinational repair in Ustilago maydisThe BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repairSpecificity of linear motifs that bind to a common mitogen-activated protein kinase docking grooveDeficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joiningTrypanosoma brucei BRCA2 acts in antigenic variation and has undergone a recent expansion in BRC repeat number that is important during homologous recombinationDistinct functions of BRCA1 and BRCA2 in double-strand break repairHomologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteinsMolding BRCA2 function through its interacting partnersDSS1 is required for the stability of BRCA2M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complexInhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2Unraveling the mechanism of BRCA2 in homologous recombinationInterrogation of the protein-protein interactions between human BRCA2 BRC repeats and RAD51 reveals atomistic determinants of affinityRole for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombinationPygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylationHomologs of breast cancer genes in plantsRAD-51-dependent and -independent roles of a Caenorhabditis elegans BRCA2-related protein during DNA double-strand break repair.Brh2-Dss1 interplay enables properly controlled recombination in Ustilago maydis.Drosophila brca2 is required for mitotic and meiotic DNA repair and efficient activation of the meiotic recombination checkpointA novel role of the chromokinesin Kif4A in DNA damage response.Targeting tumor suppressor networks for cancer therapeutics.DNA double strand break repair and its association with inherited predispositions to breast cancerSingle-molecule imaging brings Rad51 nucleoprotein filaments into focus.ASCIZ regulates lesion-specific Rad51 focus formation and apoptosis after methylating DNA damage.Integrated evaluation of DNA sequence variants of unknown clinical significance: application to BRCA1 and BRCA2Design of potent inhibitors of human RAD51 recombinase based on BRC motifs of BRCA2 protein: modeling and experimental validation of a chimera peptide.Deletion of BRCA2 exon 27 causes defects in response to both stalled and collapsed replication forksPlasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains.BRCA2 is a mediator of RAD51- and DMC1-facilitated homologous recombination in Arabidopsis thaliana.RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cellsATM, a central controller of cellular responses to DNA damage.
P2860
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P2860
Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control
description
1999 nî lūn-bûn
@nan
1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
name
Expression of BRC repeats in b ...... s of G(2)/M checkpoint control
@ast
Expression of BRC repeats in b ...... s of G(2)/M checkpoint control
@en
Expression of BRC repeats in b ...... s of G(2)/M checkpoint control
@en-gb
Expression of BRC repeats in b ...... s of G(2)/M checkpoint control
@nl
type
label
Expression of BRC repeats in b ...... s of G(2)/M checkpoint control
@ast
Expression of BRC repeats in b ...... s of G(2)/M checkpoint control
@en
Expression of BRC repeats in b ...... s of G(2)/M checkpoint control
@en-gb
Expression of BRC repeats in b ...... s of G(2)/M checkpoint control
@nl
prefLabel
Expression of BRC repeats in b ...... s of G(2)/M checkpoint control
@ast
Expression of BRC repeats in b ...... s of G(2)/M checkpoint control
@en
Expression of BRC repeats in b ...... s of G(2)/M checkpoint control
@en-gb
Expression of BRC repeats in b ...... s of G(2)/M checkpoint control
@nl
P2093
P2860
P356
P1476
Expression of BRC repeats in b ...... s of G(2)/M checkpoint control
@en
P2093
P2860
P304
P356
10.1074/JBC.274.46.32931
P407
P577
1999-11-12T00:00:00Z