Marked differences between two isoforms of human pyruvate dehydrogenase kinase
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Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenaseSolution structure and dynamics of the lipoic acid-bearing domain of human mitochondrial branched-chain alpha-keto acid dehydrogenase complexCrystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complexOverexpression of pyruvate dehydrogenase kinase 3 increases drug resistance and early recurrence in colon cancerPyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activityInduction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistancePivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetateDistinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicolInteraction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complexStructure of pyruvate dehydrogenase kinase. Novel folding pattern for a serine protein kinasePost-Translational Modifications of Cardiac Mitochondrial Proteins in Cardiovascular Disease: Not Lost in TranslationPyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and CancersStructural and Functional Insights into the Molecular Mechanisms Responsible for the Regulation of Pyruvate Dehydrogenase Kinase 2Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding PocketFacilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferaseThe C-terminal hinge region of lipoic acid-bearing domain of E2b is essential for domain interaction with branched-chain alpha-keto acid dehydrogenase kinaseDown-regulation of pyruvate dehydrogenase phosphatase in obese subjects is a defect that signals insulin resistanceAllosteric coupling in pyruvate dehydrogenase kinase 2A new locus for X-linked dominant Charcot-Marie-Tooth disease (CMTX6) is caused by mutations in the pyruvate dehydrogenase kinase isoenzyme 3 (PDK3) gene.Pharmacologically increased tumor hypoxia can be measured by 18F-Fluoroazomycin arabinoside positron emission tomography and enhances tumor response to hypoxic cytotoxin PR-104Pyruvate dehydrogenase kinase as a potential therapeutic target for malignant gliomas.Regulation of pyruvate metabolism and human diseasePhenylbutyrate therapy for pyruvate dehydrogenase complex deficiency and lactic acidosis.Probing the mechanism of inactivation of human pyruvate dehydrogenase by phosphorylation of three sites.Role of pyruvate dehydrogenase kinase 4 in regulation of blood glucose levels.Structural determinants for cross-talk between pyruvate dehydrogenase kinase 3 and lipoyl domain 2 of the human pyruvate dehydrogenase complex.Mechanisms underlying regulation of the expression and activities of the mammalian pyruvate dehydrogenase kinases.Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1.Pyruvate dehydrogenase complex: metabolic link to ischemic brain injury and target of oxidative stressDifferential inhibition of PDKs by phenylbutyrate and enhancement of pyruvate dehydrogenase complex activity by combination with dichloroacetateMitochondrial inhibitor as a new class of insulin sensitizer.Mitochondrial mutations contribute to HIF1alpha accumulation via increased reactive oxygen species and up-regulated pyruvate dehydrogenease kinase 2 in head and neck squamous cell carcinomaCrosstalk among proteome, acetylome and succinylome in colon cancer HCT116 cell treated with sodium dichloroacetateDetection of pyruvate dehydrogenase E1 alpha-subunit deficiencies in females by immunohistochemical demonstration of mosaicism in cultured fibroblasts.Global view of cognate kinase activation by the human pyruvate dehydrogenase complex.Role of protein-protein interactions in the regulation of pyruvate dehydrogenase kinase activity.The carboxy-terminal tail of pyruvate dehydrogenase kinase 2 is required for the kinase activity.Recognition of the inner lipoyl-bearing domain of dihydrolipoyl transacetylase and of the blood glucose-lowering compound AZD7545 by pyruvate dehydrogenase kinase 2.Insulin stimulation of pyruvate dehydrogenase in adipocytes involves two distinct signalling pathways.Comparative homology modeling of pyruvate dehydrogenase kinase isozymes from Xenopus tropicalis reveals structural basis for their subfunctionalization.
P2860
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P2860
Marked differences between two isoforms of human pyruvate dehydrogenase kinase
description
2000 nî lūn-bûn
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2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2000 թվականի մայիսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
@zh-mo
2000年論文
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2000年论文
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name
Marked differences between two isoforms of human pyruvate dehydrogenase kinase
@ast
Marked differences between two isoforms of human pyruvate dehydrogenase kinase
@en
Marked differences between two isoforms of human pyruvate dehydrogenase kinase
@en-gb
Marked differences between two isoforms of human pyruvate dehydrogenase kinase
@nl
type
label
Marked differences between two isoforms of human pyruvate dehydrogenase kinase
@ast
Marked differences between two isoforms of human pyruvate dehydrogenase kinase
@en
Marked differences between two isoforms of human pyruvate dehydrogenase kinase
@en-gb
Marked differences between two isoforms of human pyruvate dehydrogenase kinase
@nl
prefLabel
Marked differences between two isoforms of human pyruvate dehydrogenase kinase
@ast
Marked differences between two isoforms of human pyruvate dehydrogenase kinase
@en
Marked differences between two isoforms of human pyruvate dehydrogenase kinase
@en-gb
Marked differences between two isoforms of human pyruvate dehydrogenase kinase
@nl
P2093
P2860
P356
P1476
Marked differences between two isoforms of human pyruvate dehydrogenase kinase
@en
P2093
P2860
P304
P356
10.1074/JBC.M909488199
P407
P577
2000-05-26T00:00:00Z