Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity - Wikidata - wikimedia - TriplyDB

Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity

Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity

http://www.wikidata.org/entity/Q24317423

about

Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate Subunit and catalytic component stoichiometries of an in vitro reconstituted human pyruvate dehydrogenase complex Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4 Structural and Biochemical Characterization of Human Mitochondrial Branched-chain -Ketoacid Dehydrogenase Phosphatase Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase Inactivation of pyruvate dehydrogenase kinase 2 by mitochondrial reactive oxygen species Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase.A new locus for X-linked dominant Charcot-Marie-Tooth disease (CMTX6) is caused by mutations in the pyruvate dehydrogenase kinase isoenzyme 3 (PDK3) gene.The pyruvate dehydrogenase complexes: structure-based function and regulation.Regulation of pyruvate metabolism and human disease Elucidation of the interaction loci of the human pyruvate dehydrogenase complex E2·E3BP core with pyruvate dehydrogenase kinase 1 and kinase 2 by H/D exchange mass spectrometry and nuclear magnetic resonance Metabolic efficiency promotes protection from pressure overload in hearts expressing slow skeletal troponin I.Differential inhibition of PDKs by phenylbutyrate and enhancement of pyruvate dehydrogenase complex activity by combination with dichloroacetate Altered regulation of PDK4 expression promotes antiestrogen resistance in human breast cancer cells Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation.Pyruvate Dehydrogenase Kinases in the Nervous System: Their Principal Functions in Neuronal-glial Metabolic Interaction and Neuro-metabolic Disorders.Computational Study on New Natural Compound Inhibitors of Pyruvate Dehydrogenase Kinases.Imidacloprid Promotes High Fat Diet-Induced Adiposity and Insulin Resistance in Male C57BL/6J Mice.Postmortem mRNA expression patterns in left ventricular myocardial tissues and their implications for forensic diagnosis of sudden cardiac death.The pyruvate dehydrogenase complex in cancer: An old metabolic gatekeeper regulated by new pathways and pharmacological agents.Pyruvate dehydrogenase as a therapeutic target for obesity cardiomyopathy.Pyruvate dehydrogenase kinase 4 exhibits a novel role in the activation of mutant KRAS, regulating cell growth in lung and colorectal tumour cells.Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes.Global view of cognate kinase activation by the human pyruvate dehydrogenase complex.VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells.Metabolic and transcriptional profiling reveals pyruvate dehydrogenase kinase 4 as a mediator of epithelial-mesenchymal transition and drug resistance in tumor cells.Regulation of Pyruvate Dehydrogenase Kinase 4 in the Heart through Degradation by the Lon Protease in Response to Mitochondrial Substrate Availability.Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer.Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors.The Pyruvate Dehydrogenase Complex and Related Assemblies in Health and Disease.A Novel Inhibitor of Pyruvate Dehydrogenase Kinase Stimulates Myocardial Carbohydrate Oxidation in Diet-Induced Obesity.Deep transcriptome sequencing reveals differences in global gene expression between normal and pale, soft, and exudative turkey meat.

P2860

9d5f7158cf8b47da60fc34860410f4cde988db34 db8e2acb64cb0c05153f78e149bd5b3bc3eeae60

P248

Q24329273-D5B83D5C-F6CB-404B-8A50-86B63E87F838 Q24336339-E22767ED-978C-4A06-88AF-F59339070FDC Q24651644-61B88AA8-48D6-4E7C-AD4C-699A95189627 Q27673456-4C7688B0-99E1-4566-8E7D-79B99F7FECBD Q27676958-11187753-BCFF-4C8A-AD98-C86BA6F3BAA0 Q27680986-FDFB5624-647B-40A8-B108-A7318EEA6667 Q28241297-0FC02A42-A962-49B7-B1FC-8A8ED6938940 Q28273438-8CDD70AA-DF1D-4FCC-8196-9C01916AA22F Q28291558-F3F06EC2-DBB5-46E9-839B-16F7B0152D13 Q30537559-1C4D3371-EE48-497C-A208-8E16FC721678 Q33761130-92AA0FD8-1F6E-4A4F-8BA7-811E2C306223 Q33764544-6E0C1EE7-843C-4511-AFAA-48E4EF9E060F Q34972253-AE37DDD8-E2DC-4B94-9AB8-E723B368E83E Q35002176-3B775B73-FE5E-4493-8930-B12D2E547FB3 Q36001522-A66C02CF-572A-434F-B589-187C90813500 Q36269713-51DA2DED-762C-42AD-95A6-ABDD21F50B63 Q36272807-F35B5BB1-844B-451B-9691-B99306DEECA4 Q36460635-FC140F26-DA06-416C-AF2A-E5B045F33E03 Q36743618-B2E5EB2E-E2D9-428E-9919-C99045306B70 Q37665143-F0F0B6BB-DBA0-4606-9EB7-F45D3E310D6F Q37671248-225EB4D0-45D3-4068-B28A-6F479E2ED49E Q38418672-D9620151-6657-46A0-AD01-E528376C9523 Q38652550-762F6478-6F05-4408-B24D-1866B6480D13 Q38686612-B845336E-7F1B-404F-A45F-651D91CA40E7 Q38834617-F0A2E1D9-0180-4C72-ADD8-E2202113D0C2 Q41859582-65EB68CE-F7A0-4AB2-AB32-38B52916527E Q41908057-041470BC-519E-4072-947A-C1A2D341D81E Q42977115-7E8AA5A7-B0B0-4DDE-830E-E91733DA85B9 Q47136557-BEA3D7F1-06B4-4A67-B7D2-B3A55E7F4375 Q47615969-679B947A-A7B6-4F3C-ADBC-A4450B085E94 Q48353659-EA0CB98C-F9EE-4993-B0B3-1835F10B77F3 Q51107132-BC563989-2631-4B78-B411-901AC88D81D0 Q54111494-40462F96-EB71-420D-92DD-DF8387FD0A0E Q54379667-0AF4A7DC-05AB-4AF2-834B-E36246D2D6F5

P2860

Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity

http://www.wikidata.org/entity/Q24317423

description

2008 nî lūn-bûn

@nan

2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

Pyruvate dehydrogenase kinase- ...... obust core-free basal activity

@ast

Pyruvate dehydrogenase kinase- ...... obust core-free basal activity

@en

Pyruvate dehydrogenase kinase- ...... obust core-free basal activity

@en-gb

Pyruvate dehydrogenase kinase- ...... obust core-free basal activity

@nl

type

label

Pyruvate dehydrogenase kinase- ...... obust core-free basal activity

@ast

Pyruvate dehydrogenase kinase- ...... obust core-free basal activity

@en

Pyruvate dehydrogenase kinase- ...... obust core-free basal activity

@en-gb

Pyruvate dehydrogenase kinase- ...... obust core-free basal activity

@nl

altLabel

Pyruvate Dehydrogenase Kinase- ...... obust Core-free Basal Activity

@en

prefLabel

Pyruvate dehydrogenase kinase- ...... obust core-free basal activity

@ast

Pyruvate dehydrogenase kinase- ...... obust core-free basal activity

@en

Pyruvate dehydrogenase kinase- ...... obust core-free basal activity

@en-gb

Pyruvate dehydrogenase kinase- ...... obust core-free basal activity

@nl

P1433

Q24317423-C4CBBA58-F0C5-45E7-835C-8AB6C64C7901

P1476

Q24317423-90C9CCEF-AC35-4CB8-9DC6-B71524CD4CFD

P2093

Q24317423-84B77BDC-19EB-4410-8E32-276C81BDA97D

Q24317423-A47F38AC-605A-418E-9100-0A118EFAD7A0

Q24317423-BD094A4C-169D-4663-9EA4-333ACFE34F76

Q24317423-C050CEBC-5EE2-4F40-89B6-565D6DDB5609

Q24317423-C8D9EBEB-0056-4C83-B53D-FA9DEBDC1EE6

P2860

Q24317423-123B8305-6716-4C21-87E5-50654A45FBD8

Q24317423-196D027F-5D57-4BCB-B5CF-E680A6B09C99

Q24317423-1CFBC885-2BC7-4585-BF72-C08F963BCE3C

Q24317423-1F9A02A2-CB01-4CBC-A99D-CA49D5E7D809

Q24317423-2DB45E4F-6196-492C-8DEC-9E7AD3AA01A4

Q24317423-31D55F8B-5BD1-4F9D-A2C1-40C370BAC469

Q24317423-34260CBD-D7EF-464D-8C6C-F3CF4F55BB07

Q24317423-36707877-A83E-4A5D-AC1E-CA3BF393987F

Q24317423-45C00DD7-BEE0-4F6D-BDD9-D8396B64A8E0

Q24317423-4DB7BAE7-BA9F-460B-A770-3EB39CB99248

P304

Q24317423-E233AA03-EE02-4A4F-917B-73A0E501FA8B

P31

Q24317423-A92F458D-15F3-4363-BF99-A72F6D60EBB7

P356

Q24317423-3B6B0F14-1B97-4A69-89FC-B029ACE72912

P407

Q24317423-4F4D9862-34E8-408A-9F5B-07450A47F959

P433

Q24317423-B14019F1-6A5A-4695-82FC-D1811D4FCF4C

P478

Q24317423-1427BBA1-B160-4D3A-94BC-2C4ADF3D88F9

P50

Q24317423-103C3A3C-98DA-42A4-AB71-519ACCF0C3E3

P577

Q24317423-0D18C1A9-37E5-449D-BB96-3A414A85C97F

P698

Q24317423-0C618C00-26A4-49DD-9522-589FB0FAC358

P921

Q24317423-215BAF28-E182-4C29-A5EA-271AD6883856

Q24317423-B9B51C7E-50D9-4E75-AA91-B6A6F840DB2E

Q24317423-D147F685-2879-4E40-99D2-4D350CDB6F4C

P932

Q24317423-F8F49247-3709-400B-8EF6-658525ACF88C

P356

P1433

Journal of Biological Chemistry

P1476

Pyruvate dehydrogenase kinase- ...... obust core-free basal activity

@en

P2093

David T Chuang

http://www.w3.org/2001/XMLSchema#string

Jacinta L Chuang

http://www.w3.org/2001/XMLSchema#string

Jun Li

http://www.w3.org/2001/XMLSchema#string

Masato Kato

http://www.w3.org/2001/XMLSchema#string

Shih-Chia Tso

http://www.w3.org/2001/XMLSchema#string

P2860

Marked differences between two isoforms of human pyruvate dehydrogenase kinase

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands

Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex

Dihydrolipoamide dehydrogenase-binding protein of the human pyruvate dehydrogenase complex. DNA-derived amino acid sequence, expression, and reconstitution of the pyruvate dehydrogenase complex

Cloning and characterization of PDK4 on 7q21.3 encoding a fourth pyruvate dehydrogenase kinase isoenzyme in human

Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol

Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex

Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites

Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complex

P304

25305-25315

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M802249200

http://www.w3.org/2001/XMLSchema#string

P407

P433

37

http://www.w3.org/2001/XMLSchema#string

P478

283

http://www.w3.org/2001/XMLSchema#string

P50

P577

2008-07-24T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

18658136

http://www.w3.org/2001/XMLSchema#string

P921

Pyruvate dehydrogenase kinase 4

P932

2533096

http://www.w3.org/2001/XMLSchema#string