MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain
about
Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosisProteins associated with the exon junction complex also control the alternative splicing of apoptotic regulatorsProapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.MCL-1ES, a novel variant of MCL-1, associates with MCL-1L and induces mitochondrial cell deathSelection of novel mediators of E2F1-induced apoptosis through retroviral expression of an antisense cDNA libraryModulating splicing with small molecular inhibitors of the spliceosomeConnecting the speckles: Splicing kinases and their role in tumorigenesis and treatment responseThe two faces of miR-29The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizerThe conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cellsRegulatory non-coding RNA: new instruments in the orchestration of cell deathTankyrase 1 interacts with Mcl-1 proteins and inhibits their regulation of apoptosisRegulation of Mcl-1 by SRSF1 and SRSF5 in cancer cellsTranscriptome sequencing of tumor subpopulations reveals a spectrum of therapeutic options for squamous cell lung cancerIL-6 regulates Mcl-1L expression through the JAK/PI3K/Akt/CREB signaling pathway in hepatocytes: implication of an anti-apoptotic role during liver regenerationThe functional differences between pro-survival and pro-apoptotic B cell lymphoma 2 (Bcl-2) proteins depend on structural differences in their Bcl-2 homology 3 (BH3) domains.Intrinsically disordered proteins in bcl-2 regulated apoptosis.Modulation of Mcl-1 expression reduces age-related cochlear degenerationDifferential expression of apoptosis-related genes in the cochlea of noise-exposed rats.MCL-1 is modulated in Crohn's disease fibrosis by miR-29b via IL-6 and IL-8An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cellsDynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearanceEstrogen regulation of anti-apoptotic Bcl-2 family member Mcl-1 expression in breast cancer cellsDefective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes to lymphoma.Gene expression pattern in swine neutrophils after lipopolysaccharide exposure: a time course comparison.From General Aberrant Alternative Splicing in Cancers and Its Therapeutic Application to the Discovery of an Oncogenic DMTF1 Isoform.BAX/BAK-independent mitoptosis during cell death induced by proteasome inhibition?BH3-only proteins in apoptosis and beyond: an overview.Elevated SRPK1 lessens apoptosis in breast cancer cells through RBM4-regulated splicing events.DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cellsRole of MicroRNAs in Hepatocellular Carcinomaα-Tomatine-mediated anti-cancer activity in vitro and in vivo through cell cycle- and caspase-independent pathwaysOverexpression of Mcl-1L splice variant is associated with poor prognosis and chemoresistance in oral cancers.MCL-1ES induces MCL-1L-dependent BAX- and BAK-independent mitochondrial apoptosis.Persistent Chlamydia trachomatis infection of HeLa cells mediates apoptosis resistance through a Chlamydia protease-like activity factor-independent mechanism and induces high mobility group box 1 release.DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosisRegulation of chemoresistance via alternative messenger RNA splicingHypoxic switch in mitochondrial myeloid cell leukemia factor-1/Mtd apoptotic rheostat contributes to human trophoblast cell death in preeclampsia.Polymer nanoparticle-mediated delivery of microRNA inhibition and alternative splicingAntisense therapy for cancer.
P2860
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P248
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P2860
MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain
description
2000 nî lūn-bûn
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2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի օգոստոսին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
MCL-1S, a splicing variant of ...... possessing only the BH3 domain
@ast
MCL-1S, a splicing variant of ...... possessing only the BH3 domain
@en
MCL-1S, a splicing variant of ...... possessing only the BH3 domain
@en-gb
MCL-1S, a splicing variant of ...... possessing only the BH3 domain
@nl
type
label
MCL-1S, a splicing variant of ...... possessing only the BH3 domain
@ast
MCL-1S, a splicing variant of ...... possessing only the BH3 domain
@en
MCL-1S, a splicing variant of ...... possessing only the BH3 domain
@en-gb
MCL-1S, a splicing variant of ...... possessing only the BH3 domain
@nl
prefLabel
MCL-1S, a splicing variant of ...... possessing only the BH3 domain
@ast
MCL-1S, a splicing variant of ...... possessing only the BH3 domain
@en
MCL-1S, a splicing variant of ...... possessing only the BH3 domain
@en-gb
MCL-1S, a splicing variant of ...... possessing only the BH3 domain
@nl
P2093
P2860
P921
P3181
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P1476
MCL-1S, a splicing variant of ...... possessing only the BH3 domain
@en
P2093
P2860
P304
P3181
P356
10.1074/JBC.M909826199
P407
P577
2000-08-18T00:00:00Z