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The blood-brain barrier: bottleneck in brain drug development

The blood-brain barrier: bottleneck in brain drug development

http://www.wikidata.org/entity/Q22336985

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Early invasion of brain parenchyma by African trypanosomes GSVD comparison of patient-matched normal and tumor aCGH profiles reveals global copy-number alterations predicting glioblastoma multiforme survival Recent developments of protein kinase inhibitors as potential AD therapeutics Uptake of ANG1005, a novel paclitaxel derivative, through the blood-brain barrier into brain and experimental brain metastases of breast cancer Cancer and the blood-brain barrier: 'Trojan horses' for courses?Drug Design for CNS Diseases: Polypharmacological Profiling of Compounds Using Cheminformatic, 3D-QSAR and Virtual Screening Methodologies Microfluidic organ-on-chip technology for blood-brain barrier research Brain metastasis in human epidermal growth factor receptor 2-positive breast cancer: from biology to treatment Systemic delivery to central nervous system by engineered PLGA nanoparticles Neurotransmitters as food supplements: the effects of GABA on brain and behavior Facilitation of Drug Transport across the Blood-Brain Barrier with Ultrasound and Microbubbles.Neuroprotective Strategies after Neonatal Hypoxic Ischemic Encephalopathy Adenosine receptor signaling: a key to opening the blood-brain door The TWEAK receptor Fn14 is a potential cell surface portal for targeted delivery of glioblastoma therapeutics Targeting heat shock proteins to modulate α-synuclein toxicity Dendrimer advances for the central nervous system delivery of therapeutics Bench-to-bedside translation of magnetic nanoparticles Gene-environment interactions in Parkinson's disease: specific evidence in humans and mammalian models Rational approaches to improving selectivity in drug design Multifunctional nanoparticles for brain tumor imaging and therapy.Ultrasound enhanced drug delivery to the brain and central nervous system.Epigenetics of Alzheimer's disease and frontotemporal dementia Developmental and pathological angiogenesis in the central nervous system Blood-CNS Barrier Impairment in ALS patients versus an animal model Nanoscale drug delivery systems and the blood-brain barrier Monocyte Trafficking, Engraftment, and Delivery of Nanoparticles and an Exogenous Gene into the Acutely Inflamed Brain Tissue - Evaluations on Monocyte-Based Delivery System for the Central Nervous System Nitric oxide synthase dysfunction contributes to impaired cerebroarteriolar reactivity in experimental cerebral malaria Transporters at CNS barrier sites: obstacles or opportunities for drug delivery?Checkpoints to the Brain: Directing Myeloid Cell Migration to the Central Nervous System New therapeutic approaches for Krabbe disease: The potential of pharmacological chaperones Non-Viral Nucleic Acid Delivery Strategies to the Central Nervous System Drug and gene delivery across the blood-brain barrier with focused ultrasound Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier.The Role of Muscarinic Receptors in the Pathophysiology of Mood Disorders: A Potential Novel Treatment?Developing therapeutic approaches for metachromatic leukodystrophy Nanoparticles for imaging and treating brain cancer Pharmacokinetics of quinacrine efflux from mouse brain via the P-glycoprotein efflux transporter Uptake mechanism of ApoE-modified nanoparticles on brain capillary endothelial cells as a blood-brain barrier model Targeted and reversible blood-retinal barrier disruption via focused ultrasound and microbubbles Pharmacokinetic analysis of 111 in-labeled liposomal Doxorubicin in murine glioblastoma after blood-brain barrier disruption by focused ultrasound.

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The blood-brain barrier: bottleneck in brain drug development

http://www.wikidata.org/entity/Q22336985

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2005 nî lūn-bûn

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2005 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2005 թվականի հունվարին հրատարակված գիտական հոդված

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2005年の論文

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The blood-brain barrier: bottleneck in brain drug development

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The blood-brain barrier: bottleneck in brain drug development

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P2860

Transport of steroid hormones through the rat blood-brain barrier. Primary role of albumin-bound hormone

Selective expression of the large neutral amino acid transporter at the blood-brain barrier

A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

Drug-like properties and the causes of poor solubility and poor permeability.

Cloned blood-brain barrier adenosine transporter is identical to the rat concentrative Na+ nucleoside cotransporter CNT2.

Characterization of the blood-brain barrier choline transporter using the in situ rat brain perfusion technique.

Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood-brain barrier breakdown in vivo.

Mediated efflux of IgG molecules from brain to blood across the blood-brain barrier.

Peripheral injections of Freund's adjuvant in mice provoke leakage of serum proteins through the blood-brain barrier without inducing reactive gliosis.

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blood–brain barrier

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