Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1 - Wikidata - wikimedia - TriplyDB

Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1

Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1

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MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis The overexpression of MCPH1 inhibits cell growth through regulating cell cycle-related proteins and activating cytochrome c-caspase 3 signaling in cervical cancer Autosomal Recessive Primary Microcephaly (MCPH): clinical manifestations, genetic heterogeneity and mutation continuum A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size Shelterin complex and associated factors at human telomeres Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation Establishment of a mouse model with misregulated chromosome condensation due to defective Mcph1 function A Pocket on the Surface of the N-Terminal BRCT Domain of Mcph1 Is Required to Prevent Abnormal Chromosome Condensation Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1 Molecular Basis for the Association of Microcephalin (MCPH1) Protein with the Cell Division Cycle Protein 27 (Cdc27) Subunit of the Anaphase-promoting Complex Roles of Chk1 in cell biology and cancer therapy MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling Human brain evolution: harnessing the genomics (r)evolution to link genes, cognition, and behavior Autosomal recessive primary microcephaly (MCPH): a review of clinical, molecular, and evolutionary findings DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM Replication independent ATR signalling leads to G2/M arrest requiring Nbs1, 53BP1 and MDC1.Viral regulation of aquaporin 4, connexin 43, microcephalin and nucleolin Microcephaly models in the developing zebrafish retinal neuroepithelium point to an underlying defect in metaphase progression.Role of BRCA1 in brain development.Positive selection on the nonhomologous end-joining factor Cernunnos-XLF in the human lineage BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer MCPH1: a window into brain development and evolution.Genetics and biology of microcephaly and lissencephaly BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice.Differential patterns of allelic loss in estrogen receptor-positive infiltrating lobular and ductal breast cancer.Regulation of the BRCA1 gene by an SRC3/53BP1 complex BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly.Primary microcephaly gene MCPH1 shows a novel molecular biomarker of human renal carcinoma and is regulated by miR-27a.A novel MCPH1 isoform complements the defective chromosome condensation of human MCPH1-deficient cells.MCPH1 regulates chromosome condensation and shaping as a composite modulator of condensin II.Phosphorylation of the BRCA1 C terminus (BRCT) repeat inhibitor of hTERT (BRIT1) protein coordinates TopBP1 protein recruitment and amplifies ataxia telangiectasia-mutated and Rad3-related (ATR) Signaling ASPM and microcephalin expression in epithelial ovarian cancer correlates with tumour grade and survival The centrosome and its duplication cycle SET nuclear oncogene associates with microcephalin/MCPH1 and regulates chromosome condensation The Impact of Preeclampsia on Gene Expression at the Maternal-Fetal Interface.DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells Quantitative analysis of somatosensory cortex development in eutherians, with a comparison with metatherians and monotremes.Molecular genetics of human primary microcephaly: an overview.Chromodomain helicase DNA-binding protein 4 (CHD4) regulates homologous recombination DNA repair, and its deficiency sensitizes cells to poly(ADP-ribose) polymerase (PARP) inhibitor treatment.

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Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1

http://www.wikidata.org/entity/Q22337187

description

2004 nî lūn-bûn

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2004 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի հունիսին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1

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Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1

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Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1

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Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1

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Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1

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Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1

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Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1

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Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1

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Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1

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Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1

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Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1

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Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1

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Journal of Biological Chemistry

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Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1

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D. F. Stern

http://www.w3.org/2001/XMLSchema#string

J. Lee

http://www.w3.org/2001/XMLSchema#string

X. Xu

http://www.w3.org/2001/XMLSchema#string

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Identification of microcephalin, a protein implicated in determining the size of the human brain

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

MDC1 is a mediator of the mammalian DNA damage checkpoint

The BRCT domain is a phospho-protein binding domain

Multiple tumor suppressor pathways negatively regulate telomerase

Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage

NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

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34091-34094

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scholarly article

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10.1074/JBC.C400139200

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33

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279

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2004-06-25T00:00:00Z

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15220350

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