BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
about
Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapyMicrocephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1BRCA1 interacts with FHL2 and enhances FHL2 transactivation functionBRCA1 participates in DNA decatenationRoles of BRCA1 in centrosome duplicationA DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signalingDNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domainsNEK11 regulates CDC25A degradation and the IR-induced G2/M checkpointMERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaksCCDC98 targets BRCA1 to DNA damage sitesActivation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damageBRCT domain-containing protein PTIP is essential for progression through mitosisHuman Claspin works with BRCA1 to both positively and negatively regulate cell proliferationStructural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domainsChk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathwayRegulation of BRCA1 expression and its relationship to sporadic breast cancerBRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolutionHsp90: A New Player in DNA Repair?Non-targeted effects of ionising radiation--implications for low dose risk.The BRCA1 Breast Cancer Suppressor: Regulation of Transport, Dynamics, and Function at Multiple Subcellular LocationsMediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint controlNFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways53BP1 is associated with replication protein A and is required for RPA2 hyperphosphorylation following DNA damageBRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transitionCellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insightsHuman claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structuresRoles of Chk1 in cell biology and cancer therapyGamma-irradiation-induced DNA damage checkpoint activation involves feedback regulation between extracellular signal-regulated kinase 1/2 and BRCA1BRCA1 targets G2/M cell cycle proteins for ubiquitination and proteasomal degradationIonizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366Histone ubiquitination associates with BRCA1-dependent DNA damage responseBRCA1 is required for common-fragile-site stability via its G2/M checkpoint functionGenetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closureDNA IR-Double Strand Breaks (DSBs) and cellular response via ATMViral transport of DNA damage that mimics a stalled replication fork.Murine Wee1 plays a critical role in cell cycle regulation and pre-implantation stages of embryonic development.Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions.Chemogenomics approaches to novel target discovery.45S rDNA regions are chromosome fragile sites expressed as gaps in vitro on metaphase chromosomes of root-tip meristematic cells in Lolium spp.Human RPA phosphorylation by ATR stimulates DNA synthesis and prevents ssDNA accumulation during DNA-replication stress
P2860
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P2860
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
description
2002 nî lūn-bûn
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2002 թուականի Մարտին հրատարակուած գիտական յօդուած
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2002 թվականի մարտին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
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2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
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2002年論文
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2002年论文
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name
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
@ast
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
@en
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
@en-gb
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
@nl
type
label
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
@ast
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
@en
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
@en-gb
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
@nl
prefLabel
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
@ast
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
@en
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
@en-gb
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
@nl
P2093
P3181
P356
P1433
P1476
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
@en
P2093
Kenneth H Cowan
Lawrence C Brody
Magda Sgagias
Ronit I Yarden
Sherly Pardo-Reoyo
P2888
P3181
P356
10.1038/NG837
P407
P577
2002-03-01T00:00:00Z
P5875
P6179
1052129495