about
P688
Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesisFLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylationFolliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signalingInteraction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) proteinInactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localizationTumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signalingChronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα.Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPasesThe folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.Folliculin directs the formation of a Rab34-RILP complex to control the nutrient-dependent dynamic distribution of lysosomes.Birt-Hogg-Dube syndrome is a novel ciliopathy.GATOR1-dependent recruitment of FLCN-FNIP to lysosomes coordinates Rag GTPase heterodimer nucleotide status in response to amino acids.Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complexCryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex
P921
Q24298493-92564CA0-6831-43DA-BC04-F6077C3F58EFQ24302037-5397426A-DA86-438D-B4FB-94E9DE86352FQ24306277-323EEDE5-E099-43C6-8DFC-1A496D967912Q24318494-D6049DED-A6D7-4C9F-A6B5-6263E689C025Q24324012-2BD2C0BC-A54A-4670-9990-68368D0E59C6Q24329165-7FDC15F1-B09A-4A8B-AB1B-3CF01A2377E7Q36891685-0A287479-A714-49B9-BA4A-48E8AA671DEDQ37208207-79DA6722-82C6-4A68-88D0-8776BAAE22A5Q37402791-57FE2B69-BBC7-4C6B-847A-4D8FDD23DF7EQ38775363-A3A6800B-E88C-46FF-BCF1-19D485FBD057Q39137512-65082B37-E5BE-4DF7-BB4F-B22754CA30EBQ64911975-80CE89E8-189B-4F7A-843B-3544B5AD92A6Q91044446-266F7698-1B49-42BF-AAB9-31A535B03BCDQ91194064-ADB39691-17FB-46D9-80B6-A494F2363ACC
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
proteïne in Folliculin
@nl
protèin
@ace
بروتين في الإنسان العاقل
@ar
name
Folliculin
@en
type
label
Folliculin
@en
altLabel
BHD skin lesion fibrofolliculoma protein
@en
FLCN
@en
birt-Hogg-Dube syndrome protein
@en
folliculin
@en
prefLabel
Folliculin
@en
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NP_001340158
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XP_011522016
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ENSP00000285071
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ENSP00000410410
ENSP00000463970