Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization
about
FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylationAccessory proteins for heterotrimeric G-proteins in the kidneyActivators of G protein signaling in the kidneyThe metabolic basis of kidney cancerExpression and knockdown of zebrafish folliculin suggests requirement for embryonic brain morphogenesis.Beyond indigestion: emerging roles for lysosome-based signaling in human diseaseRegulation of mitochondrial oxidative metabolism by tumor suppressor FLCNThe folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dubé syndrome is required for murine B-cell developmentExit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3Birt-Hogg-Dubé: tumour suppressor function and signalling dynamics central to folliculin.Clinical and genetic characteristics of chinese patients with Birt-Hogg-Dubé syndromeFolliculin (Flcn) inactivation leads to murine cardiac hypertrophy through mTORC1 deregulationDistinctive expression patterns of glycoprotein non-metastatic B and folliculin in renal tumors in patients with Birt-Hogg-Dubé syndrome.Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn.Pulmonary manifestations of Birt-Hogg-Dubé syndrome.Pulmonary Neoplasms in Patients with Birt-Hogg-Dubé Syndrome: Histopathological Features and Genetic and Somatic Events.Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancersAberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathwayClinical Features, Genetics and Potential Therapeutic Approaches for Birt-Hogg-Dubé Syndrome.The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debrisBirt-Hogg-Dubé syndrome: from gene discovery to molecularly targeted therapies.Loss of Folliculin Disrupts Hematopoietic Stem Cell Quiescence and Homeostasis Resulting in Bone Marrow Failure.Evidence for pericyte origin of TSC-associated renal angiomyolipomas and implications for angiotensin receptor inhibition therapy.Genetic modification of dividing cells using episomally maintained S/MAR DNA vectors.Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPasesMolecular genetics and clinical features of Birt-Hogg-Dubé syndrome.Genomic heterogeneity of translocation renal cell carcinomaThe tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissueBirt-Hogg-Dubé syndrome: a case report and a review of the literature.Hereditary renal cell carcinoma: genetics, clinical features, and surgical considerations.Current models of mammalian target of rapamycin complex 1 (mTORC1) activation by growth factors and amino acids.ALK-rearranged renal cell carcinomas in children.Establishment and characterization of BHD-F59RSVT, an immortalized cell line derived from a renal cell carcinoma in a patient with Birt-Hogg-Dubé syndrome.Folliculin directs the formation of a Rab34-RILP complex to control the nutrient-dependent dynamic distribution of lysosomes.Glycogen synthase kinase-3 (GSK3) inhibition induces prosurvival autophagic signals in human pancreatic cancer cells.Birt-Hogg-Dube syndrome is a novel ciliopathy.Folliculin - A tumor suppressor at the intersection of metabolic signaling and membrane traffic.Rags to riches: Amino acid sensing by the Rag GTPases in health and disease.Recurrent renal cancer in Birt-Hogg-Dubé syndrome: A case report.FLCN: The causative gene for Birt-Hogg-Dubé syndrome.
P2860
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P248
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P2860
Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization
description
2010 nî lūn-bûn
@nan
2010 թուականին հրատարակուած գիտական յօդուած
@hyw
2010 թվականին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Inactivation of the FLCN tumor ...... asing its nuclear localization
@ast
Inactivation of the FLCN tumor ...... asing its nuclear localization
@en
Inactivation of the FLCN tumor ...... asing its nuclear localization
@en-gb
Inactivation of the FLCN tumor ...... asing its nuclear localization
@nl
type
label
Inactivation of the FLCN tumor ...... asing its nuclear localization
@ast
Inactivation of the FLCN tumor ...... asing its nuclear localization
@en
Inactivation of the FLCN tumor ...... asing its nuclear localization
@en-gb
Inactivation of the FLCN tumor ...... asing its nuclear localization
@nl
prefLabel
Inactivation of the FLCN tumor ...... asing its nuclear localization
@ast
Inactivation of the FLCN tumor ...... asing its nuclear localization
@en
Inactivation of the FLCN tumor ...... asing its nuclear localization
@en-gb
Inactivation of the FLCN tumor ...... asing its nuclear localization
@nl
P2093
P2860
P921
P3181
P1433
P1476
Inactivation of the FLCN tumor ...... asing its nuclear localization
@en
P2093
HyoungBin Oh
Laura S Schmidt
Seung-Beom Hong
Vladimir A Valera
W Marston Linehan
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0015793
P407
P50
P577
2010-01-01T00:00:00Z