Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins
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Nucleic Acid sensors and type I interferon production in systemic lupus erythematosusStructural basis for the dsRNA specificity of the Lassa virus NP exonucleaseStructural insights into DNA repair by RNase T--an exonuclease processing 3' end of structured DNA in repair pathwaysAn orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasomeMre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activityTrex1 prevents cell-intrinsic initiation of autoimmunityBiochemical and cellular characteristics of the 3' -> 5' exonuclease TREX2Transcriptional regulation of human DNA repair genes following genotoxic stress: trigger mechanisms, inducible responses and genotoxic adaptationThe crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partneringStructure of the dimeric exonuclease TREX1 in complex with DNA displays a proline-rich binding site for WW DomainsStructure of the sulphiredoxin–peroxiredoxin complex reveals an essential repair embraceStructural and biochemical studies of TREX1 inhibition by metals. Identification of a new active histidine conserved in DEDDh exonucleasesCrystal Structure of CRN-4: Implications for Domain Function in Apoptotic DNA DegradationDefects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune diseaseRecognition and processing of double-stranded DNA by ExoX, a distributive 3'-5' exonucleaseRAD51 mutants cause replication defects and chromosomal instabilityThe human TREX2 3' -> 5'-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysisMouse models for Aicardi-Goutières syndrome provide clues to the molecular pathogenesis of systemic autoimmunityAicardi-Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletionThe Arg-62 residues of the TREX1 exonuclease act across the dimer interface contributing to catalysis in the opposing protomers.Yeast Tdp1 regulates the fidelity of nonhomologous end joining.RNaseH2 mutants that cause Aicardi-Goutieres syndrome are active nucleasesHigh frequency targeted mutagenesis using engineered endonucleases and DNA-end processing enzymes.The 3'-5' DNA exonuclease TREX1 directly interacts with poly(ADP-ribose) polymerase-1 (PARP1) during the DNA damage response.Functional consequences of the RNase H2A subunit mutations that cause Aicardi-Goutieres syndrome.Dominant mutation of the TREX1 exonuclease gene in lupus and Aicardi-Goutieres syndrome.Trex2 enables spontaneous sister chromatid exchanges without facilitating DNA double-strand break repair.Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease.The TREX1 exonuclease R114H mutation in Aicardi-Goutières syndrome and lupus reveals dimeric structure requirements for DNA degradation activity.The danger model approach to the pathogenesis of the rheumatic diseases.Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis.Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome.Human DNA Exonuclease TREX1 Is Also an Exoribonuclease That Acts on Single-stranded RNA.WRN exonuclease activity is blocked by DNA termini harboring 3' obstructive groups.The role of DNA exonucleases in protecting genome stability and their impact on ageing.TREX1 acts in degrading damaged DNA from drug-treated tumor cells.Characterization of the 3' --> 5' exonuclease activity found in human nucleoside diphosphate kinase 1 (NDK1) and several of its homologues.DNA binding induces active site conformational change in the human TREX2 3'-exonucleaseEarly onset of autoimmune disease by the retroviral integrase inhibitor raltegravir.Migraine and genetic and acquired vasculopathies.
P2860
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P2860
Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins
description
2001 nî lūn-bûn
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2001 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2001 թվականի մայիսին հրատարակված գիտական հոդված
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2001年の論文
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2001年学术文章
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2001年学术文章
@zh-cn
2001年学术文章
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2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
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name
Excision of 3' termini by the ...... on of the recombinant proteins
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Excision of 3' termini by the ...... on of the recombinant proteins
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Excision of 3' termini by the ...... on of the recombinant proteins
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Excision of 3' termini by the ...... on of the recombinant proteins
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Excision of 3' termini by the ...... on of the recombinant proteins
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Excision of 3' termini by the ...... on of the recombinant proteins
@en
Excision of 3' termini by the ...... on of the recombinant proteins
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Excision of 3' termini by the ...... on of the recombinant proteins
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Excision of 3' termini by the ...... on of the recombinant proteins
@ast
Excision of 3' termini by the ...... on of the recombinant proteins
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Excision of 3' termini by the ...... on of the recombinant proteins
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Excision of 3' termini by the ...... on of the recombinant proteins
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P2860
P356
P1476
Excision of 3' termini by the ...... on of the recombinant proteins
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P2093
F W Perrino
P2860
P304
P356
10.1074/JBC.M100623200
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P577
2001-05-18T00:00:00Z