Isolation and characterization of the human MRE11 homologue
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Isolation of Ku70-binding proteins (KUBs)Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factorsStructure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genesExcision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteinsHuman Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repairUV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalizationComponents of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing.Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complexhMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaksDNA end resection: many nucleases make light workDistinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination.The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance.A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous RecombinationAnalysis of 11q21-24 loss of heterozygosity candidate target genes in breast cancer: indications of TSLC1 promoter hypermethylationRole of MRE11 in cell proliferation, tumor invasion, and DNA repair in breast cancerConditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cellsThe MRE11-NBS1-RAD50 pathway is perturbed in SV40 large T antigen-immortalized AT-1, AT-2 and HL-1 cardiomyocytes.Role of RAD52 epistasis group genes in homologous recombination and double-strand break repairA phylogenomic study of DNA repair genes, proteins, and processes.DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression.Active role for nibrin in the kinetics of atm activationATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaksAlteration of N-terminal phosphoesterase signature motifs inactivates Saccharomyces cerevisiae Mre11.An mre11 mutant of Coprinus cinereus has defects in meiotic chromosome pairing, condensation and synapsis.The SbcCD nuclease of Escherichia coli is a structural maintenance of chromosomes (SMC) family protein that cleaves hairpin DNAA new connection at human telomeres: association of the Mre11 complex with TRF2.Molecular basis of ataxia telangiectasia and related diseases.DNA End Resection: Nucleases Team Up with the Right Partners to Initiate Homologous RecombinationThe role of NBS1 in the modulation of PIKK family proteins ATM and ATR in the cellular response to DNA damageNijmegen breakage syndrome cells fail to induce the p53-mediated DNA damage response following exposure to ionizing radiationPalindrome resolution and recombination in the mammalian germ line.The Drosophila melanogaster RAD54 homolog, DmRAD54, is involved in the repair of radiation damage and recombination.Nbs1-dependent binding of Mre11 to adenovirus E4 mutant viral DNA is important for inhibiting DNA replication.Coprinus cinereus rad50 mutants reveal an essential structural role for Rad50 in axial element and synaptonemal complex formation, homolog pairing and meiotic recombinationMolecular cytogenetic delineation of a novel critical genomic region in chromosome bands 11q22.3-923.1 in lymphoproliferative disorders.Defective signal joint recombination in fanconi anemia fibroblasts reveals a role for Rad50 in V(D)J recombinationIdentification of the RGG box motif in Shadoo: RNA-binding and signaling roles?mre11S--a yeast mutation that blocks double-strand-break processing and permits nonhomologous synapsis in meiosisDNA-binding and strand-annealing activities of human Mre11: implications for its roles in DNA double-strand break repair pathways.DNA-PK, the DNA-activated protein kinase, is differentially expressed in normal and malignant human tissues.
P2860
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P2860
Isolation and characterization of the human MRE11 homologue
description
1995 nî lūn-bûn
@nan
1995 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Isolation and characterization of the human MRE11 homologue
@ast
Isolation and characterization of the human MRE11 homologue
@en
Isolation and characterization of the human MRE11 homologue
@en-gb
Isolation and characterization of the human MRE11 homologue
@nl
type
label
Isolation and characterization of the human MRE11 homologue
@ast
Isolation and characterization of the human MRE11 homologue
@en
Isolation and characterization of the human MRE11 homologue
@en-gb
Isolation and characterization of the human MRE11 homologue
@nl
prefLabel
Isolation and characterization of the human MRE11 homologue
@ast
Isolation and characterization of the human MRE11 homologue
@en
Isolation and characterization of the human MRE11 homologue
@en-gb
Isolation and characterization of the human MRE11 homologue
@nl
P2093
P356
P1433
P1476
Isolation and characterization of the human MRE11 homologue
@en
P2093
D T Weaver
J H Petrini
J R Korenberg
P356
10.1006/GENO.1995.1217
P407
P577
1995-09-01T00:00:00Z