Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2
about
Function, regulation and pathological roles of the Gab/DOS docking proteinsInteraction of integrin β4 with S1P receptors in S1P- and HGF-induced endothelial barrier enhancementRoles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factorDistinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cellsReduced phosphatase activity of SHP-2 in LEOPARD syndrome: consequences for PI3K binding on Gab1Identification of Fer tyrosine kinase localized on microtubules as a platelet endothelial cell adhesion molecule-1 phosphorylating kinase in vascular endothelial cellsThe docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathwayStructural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 MutationsMolecular Basis of Gain-of-Function LEOPARD Syndrome-Associated SHP2 MutationsDocking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory moleculesThe role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptorsGenetic identification of effectors downstream of Neu (ErbB-2) autophosphorylation sites in a Drosophila modelMet receptor tyrosine kinase signals through a cortactin-Gab1 scaffold complex, to mediate invadopodiaHost adaptor proteins Gab1 and CrkII promote InlB-dependent entry of Listeria monocytogenes.The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42Sequence specificity of SHP-1 and SHP-2 Src homology 2 domains. Critical roles of residues beyond the pY+3 position.SHP2 binds catalase and acquires a hydrogen peroxide-resistant phosphatase activity via integrin-signaling.SHP2 is induced by the HBx-NF-κB pathway and contributes to fibrosis during human early hepatocellular carcinoma development.Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112.SHP2E76K mutant promotes lung tumorigenesis in transgenic miceAssociation of Shp2 with phosphorylated IL-22R1 is required for interleukin-22-induced MAP kinase activation.Shp2E76K mutant confers cytokine-independent survival of TF-1 myeloid cells by up-regulating Bcl-XL.Critical role of Shp2 in tumor growth involving regulation of c-MycTargeting protein tyrosine phosphatases for anticancer drug discovery.Endothelial Grb2-associated binder 1 is crucial for postnatal angiogenesisNegative feedback of T cell activation through inhibitory adapters and costimulatory receptors.Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophyInteraction of scaffolding adaptor protein Gab1 with tyrosine phosphatase SHP2 negatively regulates IGF-I-dependent myogenic differentiation via the ERK1/2 signaling pathwayInhibition of Shp2 suppresses mutant EGFR-induced lung tumors in transgenic mouse model of lung adenocarcinoma.Structure-based kinetic models of modular signaling protein function: focus on Shp2.Critical role of Src and SHP-2 in sst2 somatostatin receptor-mediated activation of SHP-1 and inhibition of cell proliferationGab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation.Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction: is it a mechanoresponsive molecule?Discovery of a Novel Inhibitor of the Protein Tyrosine Phosphatase Shp2.Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops.Antagonism or synergism. Role of tyrosine phosphatases SHP-1 and SHP-2 in growth factor signaling.Early signaling dynamics of the epidermal growth factor receptor.Growth hormone modulation of EGF-induced PI3K-Akt pathway in mice liverThe Src homology 2 domain tyrosine phosphatases SHP-1 and SHP-2: diversified control of cell growth, inflammation, and injury.Acquired substrate preference for GAB1 protein bestows transforming activity to ERBB2 kinase lung cancer mutants.
P2860
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P2860
Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
name
Phosphotyrosines 627 and 659 o ...... binding and activation of SHP2
@ast
Phosphotyrosines 627 and 659 o ...... binding and activation of SHP2
@en
Phosphotyrosines 627 and 659 o ...... binding and activation of SHP2
@en-gb
Phosphotyrosines 627 and 659 o ...... binding and activation of SHP2
@nl
type
label
Phosphotyrosines 627 and 659 o ...... binding and activation of SHP2
@ast
Phosphotyrosines 627 and 659 o ...... binding and activation of SHP2
@en
Phosphotyrosines 627 and 659 o ...... binding and activation of SHP2
@en-gb
Phosphotyrosines 627 and 659 o ...... binding and activation of SHP2
@nl
prefLabel
Phosphotyrosines 627 and 659 o ...... binding and activation of SHP2
@ast
Phosphotyrosines 627 and 659 o ...... binding and activation of SHP2
@en
Phosphotyrosines 627 and 659 o ...... binding and activation of SHP2
@en-gb
Phosphotyrosines 627 and 659 o ...... binding and activation of SHP2
@nl
P2093
P2860
P356
P1476
Phosphotyrosines 627 and 659 o ...... binding and activation of SHP2
@en
P2093
P2860
P304
24380-24387
P356
10.1074/JBC.M010275200
P407
P50
P577
2001-04-25T00:00:00Z