Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops. - Wikidata - wikimedia - TriplyDB

Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops.

Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops.

http://www.wikidata.org/entity/Q36559220

about

Function, regulation and pathological roles of the Gab/DOS docking proteins Raf family kinases: old dogs have learned new tricks Bigger, better, faster: principles and models of AKAP anchoring protein signaling.Quantitative and logic modelling of molecular and gene networks Association rate constants of ras-effector interactions are evolutionarily conserved Simulating EGFR-ERK signaling control by scaffold proteins KSR and MP1 reveals differential ligand-sensitivity co-regulated by Cbl-CIN85 and endophilin HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer Modeling of tumor progression in NSCLC and intrinsic resistance to TKI in loss of PTEN expression Development of a human breast-cancer derived cell line stably expressing a bioluminescence resonance energy transfer (BRET)-based phosphatidyl inositol-3 phosphate (PIP3) biosensor The Mu opioid receptor promotes opioid and growth factor-induced proliferation, migration and Epithelial Mesenchymal Transition (EMT) in human lung cancer Systems biology of vascular endothelial growth factors Signalling ballet in space and time Systematic quantification of negative feedback mechanisms in the extracellular signal-regulated kinase (ERK) signaling network.Oncofinder, a new method for the analysis of intracellular signaling pathway activation using transcriptomic data.Relaxation oscillations and hierarchy of feedbacks in MAPK signaling Multistrip Western blotting to increase quantitative data output.Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins.Fuzzy logic analysis of kinase pathway crosstalk in TNF/EGF/insulin-induced signaling.Coupled stochastic spatial and non-spatial simulations of ErbB1 signaling pathways demonstrate the importance of spatial organization in signal transduction Epidermal growth factor receptor mutation in combination with expression of MIG6 alters gefitinib sensitivity.PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells Genomewide analysis of inherited variation associated with phosphorylation of PI3K/AKT/mTOR signaling proteins Systems biology modeling reveals a possible mechanism of the tumor cell death upon oncogene inactivation in EGFR addicted cancers.Complexity of receptor tyrosine kinase signal processing.Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise.Computational Model of Gab1/2-Dependent VEGFR2 Pathway to Akt Activation.Simultaneous targeting of PI3Kδ and a PI3Kδ-dependent MEK1/2-Erk1/2 pathway for therapy in pediatric B-cell acute lymphoblastic leukemia.Quantitative models of signal transduction networks: How detailed should they be?Synergy between inhibitors of androgen receptor and MEK has therapeutic implications in estrogen receptor-negative breast cancer.The mapping of yeast's G-protein coupled receptor with an atomic force microscope.Alpha1a-Adrenoceptor Genetic Variant Triggers Vascular Smooth Muscle Cell Hyperproliferation and Agonist Induced Hypertrophy via EGFR Transactivation Pathway.Abnormal hematopoiesis in Gab2 mutant mice Dynamic Modeling and Analysis of the Cross-Talk between Insulin/AKT and MAPK/ERK Signaling Pathways.Epidermal growth factor-stimulated Akt phosphorylation requires clathrin or ErbB2 but not receptor endocytosis Predictive Modeling of Drug Treatment in the Area of Personalized Medicine.Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups.Domain-oriented reduction of rule-based network models.PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk Translational research in glioblastoma multiforme: molecular criteria for patient selection.Systems-level interactions between insulin-EGF networks amplify mitogenic signaling.

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P2860

Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops.

http://www.wikidata.org/entity/Q36559220

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

2006年论文

@zh

2006年论文

@zh-cn

name

Scaffolding protein Grb2-assoc ...... tiple positive feedback loops.

@ast

Scaffolding protein Grb2-assoc ...... tiple positive feedback loops.

@en

type

label

Scaffolding protein Grb2-assoc ...... tiple positive feedback loops.

@ast

Scaffolding protein Grb2-assoc ...... tiple positive feedback loops.

@en

prefLabel

Scaffolding protein Grb2-assoc ...... tiple positive feedback loops.

@ast

Scaffolding protein Grb2-assoc ...... tiple positive feedback loops.

@en

P1433

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P1476

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P356

P1433

Journal of Biological Chemistry

P1476

Scaffolding protein Grb2-assoc ...... tiple positive feedback loops.

@en

P2093

Anatoly Kiyatkin

http://www.w3.org/2001/XMLSchema#string

Edita Aksamitiene

http://www.w3.org/2001/XMLSchema#string

Jan B Hoek

http://www.w3.org/2001/XMLSchema#string

Nick I Markevich

http://www.w3.org/2001/XMLSchema#string

Nikolay M Borisov

http://www.w3.org/2001/XMLSchema#string

P2860

Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2

Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor

A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

The PI3K-PDK1 connection: more than just a road to PKB

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif.

The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1

Ultrasensitivity in the mitogen-activated protein kinase cascade

P304

19925-19938

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P31

scholarly article

P356

10.1074/JBC.M600482200

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P407

P433

29

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P478

281

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P50

Boris Kholodenko

P577

2006-05-09T00:00:00Z

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P698

16687399

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P932

2312093

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